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• W2185970408 abstract "Recent evidence indicates that some thymic cells of developing and adult laboratory animals express the neurotrophin NGF and its low-affinity p75 NTR and high-affinity TrkA receptor. Less is known as to whether the thymus of adult and aged humans express these markers. We hypothesize that the pres- ence and distribution of immunopositive cells for NGF and NGF receptors undergo some alterations during the involution of human thymus. Specimens from nor- mal thymuses of old individuals were obtained from autopsy and surgery cases, and examined immunocyto- chemically at the light and transmission electron micro- scopic level. The immunoreactivity of NGF, p75 NTR , TrkA and cytokeratin was found in the epithelial thy- mocyte microenvironment. Our results provide the first ultrastructural evidence for NGF/receptor immunocyto- chemical localization in human thymus. They suggest a possible immunotrophic/immunoregulatory role of the NGF-p75 NTR -TrkA system for T-cell development in human thymus during senile involution." @default.
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• W2185970408 date "2003-01-01" @default.
• W2185970408 modified "2023-09-24" @default.
• W2185970408 title "Cellular Localization of NGF and NGF Receptors in Aged Human Thymus ( human thymus / involution / NGF / p75 NTR / TrkA / immunoreactivity / epithelial cells / microscopy )" @default.
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