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- W2185970674 abstract "Mouth disintegrating tablet (MDT) emerged as an alternative to the conventional oral dosage forms to improve the patient compliance. As the two extreme end age group (paediatric and geriatric) complain about the swallowing of conventional oral solid dosage forms. MDTs are solid dosage form containing medicinal substances or active ingredients which disintegrates rapidly within a few seconds when placed up on tongue. In this article the Gliclazide MDT were prepared using cross carmellose and sodium starch glycolate as superdisintegrant separately and then in combination by direct compression method. Gliclazide, second generation sulphonylurea, is an oral antihypereglycemic agent used for the treatment of non-insulin-dependent diabetes mellitus. The prepared MDT’s were evaluated for various parameters like disintegration time, wetting time, drug content, in vitro drug release study etc. From the result it was observed that among two superdisintegrants used, crosscarmellose sodium showed better result in disintegration time, in vitro drug release. The formulation of F-4 containing cross carmellose sodium (5%) showed better result in disintegration time 11 sec. and maximum in vitro drug release of 99.89 % at the end of 20 minutes." @default.
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- W2185970674 date "2013-01-01" @default.
- W2185970674 modified "2023-09-27" @default.
- W2185970674 title "Formulation and Evaluation of Glicazide Mouth Dissolving Tablets" @default.
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