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• W2185979100 abstract "Summary Bidaria khandalense extract (BKE) with high levels of polyphenol compounds has been reported to have antioxidative effects in vitro and in vivo. In this study, attention was focused on the antioxidant effect of BKE. The aim of the present study was to determine the effects of BKE on endotoxin.induced uveitis (EIU) in rats. In addition, the endotoxin. induced expression of the inducible nitric oxide synthase (iNOS) and cyclooxygenase (COX).2 proteins was determined in a mouse macrophage cell line (RAW 264.7 ) treated with BKE in vitro, to clarify the anti.inflammatory properties. EIU was induced in male Wistar rats by a footpad injection of lipopolysaccharide (LPS). Immediately after the LPS injection, 1, 10, or 100 mg BKE or 10 mg prednisolone was injected intravenously. After 24 hours, the aqueous humor was collected from both eyes, and the number of infiltrating cells, protein concentration, nitric oxide (NO), prostaglandin (PG). E2, and TNF levels in the aqueous humor were determined. RAW 264.7 cells treated with various concentrations of BKE were incubated with 10 ?g/mL LPS for 24 hours. Levels of NO, PGE2, and TNF were determined. The expression of iNOS and COX.2 proteins was analyzed by Western blot analysis. The number of inflammatory cells, the protein concentrations, and the levels of NO, PGE2, and TNF in the aqueous humor in the groups treated with BKE were significantly decreased in a dose.dependent manner. In addition, the anti inflammatory effect of 100 mg BKE was as strong as that of 10 mg prednisolone. The anti.inflammatory action of BKE was stronger than that of either quercetin or anthocyanin administered alone. BKE also suppressed LPS.induced iNOS and COX.2 protein expressions in RAW 264.7 cells in vitro in a dosedependent manner. The results suggest that BKE has a dose.dependent anti– ocular inflammatory effect that is due to the direct blocking of the expression of the iNOS and COX.2 enzymes and leads to the suppression of the production of NO, PGE2, and TNF ." @default.
• W2185979100 created "2016-06-24" @default.
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• W2185979100 date "2011-01-01" @default.
• W2185979100 modified "2023-09-27" @default.
• W2185979100 title "ANTI-INFLAMMATORY EFFECTS OF BIDARIA KHANDALENSE EXTRACT ON RAT ENDOTOXIN-INDUCED UVEITIS" @default.
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