FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2185979690> ?p ?o ?g. }

• W2185979690 endingPage "3285" @default.
• W2185979690 startingPage "3275" @default.
• W2185979690 abstract "ABSTRACT Double minutes (DMs) seen in a substantial fraction of human tumors are the cytogenetic manifestation of gene amplification which renders the tumor cells advantageous for growth and survival. DMs are acentric and atelomeric chromatin composed of circular DNA. In this study, we found they showed a remarkable relocation inside the nucleus which was spatially and temporally coupled to DNA replication. Using the human COLO 320DM tumor line, we detected DMs by fluorescence in situ hybridization followed by confocal examination. The location of multi-copy DMs was evaluated statistically by an easy method developed in this study. By examination of a synchronized culture, we found that DMs preferentially located at the nuclear periphery during G1-phase of the cell cycle, which is consistent with the location at M-phase. The peripheral DMs were in contact with the nuclear lamina which was shown by the simultaneous detection of DMs and lamin protein. The peripheral location persisted until the cells reached the G1/S-boundary, then the DMs relocated promptly to inward once the DNA replication started. The relocation was obvious using two different probes that detect DMs, or using two different methods for the cell fixation. Furthermore, the simultaneous detection of DMs and the site of DNA replication suggested that the inward relocation of peripheral DMs initiated just prior to the onset of DNA replication at the periphery. On the other hand, if the same amplified sequences were placed in a chromosome as an homogeneously staining region, they did not show any significant relocation during S-phase. From these and reported results, there may exist a generalized inward motion of some kind of chromatin that precedes the replication of their DNA. DMs might magnify the motion by their acentric, atelomeric or small circular nature." @default.
• W2185979690 created "2016-06-24" @default.
• W2185979690 creator A5020512644 @default.
• W2185979690 creator A5081693276 @default.
• W2185979690 date "1998-11-15" @default.
• W2185979690 modified "2023-09-27" @default.
• W2185979690 title "DNA replication-dependent intranuclear relocation of double minute chromatin" @default.
• W2185979690 cites W1919634504 @default.
• W2185979690 cites W1968954227 @default.
• W2185979690 cites W1972199640 @default.
• W2185979690 cites W1975241813 @default.
• W2185979690 cites W1976484209 @default.
• W2185979690 cites W1977029510 @default.
• W2185979690 cites W1983345968 @default.
• W2185979690 cites W1988073250 @default.
• W2185979690 cites W1992425415 @default.
• W2185979690 cites W2004691672 @default.
• W2185979690 cites W2010048621 @default.
• W2185979690 cites W2047289486 @default.
• W2185979690 cites W2052607570 @default.
• W2185979690 cites W2053069621 @default.
• W2185979690 cites W2055691598 @default.
• W2185979690 cites W2058123255 @default.
• W2185979690 cites W2070026305 @default.
• W2185979690 cites W2071586891 @default.
• W2185979690 cites W2071905683 @default.
• W2185979690 cites W2073882445 @default.
• W2185979690 cites W2080976322 @default.
• W2185979690 cites W2085095486 @default.
• W2185979690 cites W2087778523 @default.
• W2185979690 cites W2120321636 @default.
• W2185979690 cites W2124181908 @default.
• W2185979690 cites W2124916454 @default.
• W2185979690 cites W2128101861 @default.
• W2185979690 cites W2137970726 @default.
• W2185979690 cites W2140125310 @default.
• W2185979690 cites W2148929873 @default.
• W2185979690 cites W2151485619 @default.
• W2185979690 cites W2169727662 @default.
• W2185979690 cites W2401024104 @default.
• W2185979690 doi "https://doi.org/10.1242/jcs.111.22.3275" @default.
• W2185979690 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9788870" @default.
• W2185979690 hasPublicationYear "1998" @default.
• W2185979690 type Work @default.
• W2185979690 sameAs 2185979690 @default.
• W2185979690 citedByCount "40" @default.
• W2185979690 countsByYear W21859796902013 @default.
• W2185979690 countsByYear W21859796902015 @default.
• W2185979690 countsByYear W21859796902016 @default.
• W2185979690 countsByYear W21859796902018 @default.
• W2185979690 countsByYear W21859796902019 @default.
• W2185979690 countsByYear W21859796902020 @default.
• W2185979690 countsByYear W21859796902021 @default.
• W2185979690 countsByYear W21859796902022 @default.
• W2185979690 countsByYear W21859796902023 @default.
• W2185979690 crossrefType "journal-article" @default.
• W2185979690 hasAuthorship W2185979690A5020512644 @default.
• W2185979690 hasAuthorship W2185979690A5081693276 @default.
• W2185979690 hasConcept C104317684 @default.
• W2185979690 hasConcept C153911025 @default.
• W2185979690 hasConcept C2777542201 @default.
• W2185979690 hasConcept C2778512757 @default.
• W2185979690 hasConcept C30481170 @default.
• W2185979690 hasConcept C54355233 @default.
• W2185979690 hasConcept C552990157 @default.
• W2185979690 hasConcept C73573662 @default.
• W2185979690 hasConcept C83640560 @default.
• W2185979690 hasConcept C86803240 @default.
• W2185979690 hasConcept C95444343 @default.
• W2185979690 hasConceptScore W2185979690C104317684 @default.
• W2185979690 hasConceptScore W2185979690C153911025 @default.
• W2185979690 hasConceptScore W2185979690C2777542201 @default.
• W2185979690 hasConceptScore W2185979690C2778512757 @default.
• W2185979690 hasConceptScore W2185979690C30481170 @default.
• W2185979690 hasConceptScore W2185979690C54355233 @default.
• W2185979690 hasConceptScore W2185979690C552990157 @default.
• W2185979690 hasConceptScore W2185979690C73573662 @default.
• W2185979690 hasConceptScore W2185979690C83640560 @default.
• W2185979690 hasConceptScore W2185979690C86803240 @default.
• W2185979690 hasConceptScore W2185979690C95444343 @default.
• W2185979690 hasIssue "22" @default.
• W2185979690 hasLocation W21859796901 @default.
• W2185979690 hasLocation W21859796902 @default.
• W2185979690 hasOpenAccess W2185979690 @default.
• W2185979690 hasPrimaryLocation W21859796901 @default.
• W2185979690 hasRelatedWork W1972930779 @default.
• W2185979690 hasRelatedWork W2028172207 @default.
• W2185979690 hasRelatedWork W2076566836 @default.
• W2185979690 hasRelatedWork W2091908413 @default.
• W2185979690 hasRelatedWork W2142696743 @default.
• W2185979690 hasRelatedWork W2159207147 @default.
• W2185979690 hasRelatedWork W2514514743 @default.
• W2185979690 hasRelatedWork W3034906800 @default.
• W2185979690 hasRelatedWork W3049611764 @default.
• W2185979690 hasRelatedWork W3133382936 @default.
• W2185979690 hasVolume "111" @default.
• W2185979690 isParatext "false" @default.
• W2185979690 isRetracted "false" @default.

• next