Matches in SemOpenAlex for { <https://semopenalex.org/work/W2185984975> ?p ?o ?g. }
Showing items 1 to 93 of
93
with 100 items per page.
- W2185984975 endingPage "228" @default.
- W2185984975 startingPage "228" @default.
- W2185984975 abstract "Physalis angulata L. is an annual herb widely used as popular medicine for the treatment of cancer. Physalis angulata L. ethanolic extract (PEE) has been demonstrated to have strong cytotoxic activity against breast cancer, inhibited cancer cell’s proliferation and induced cell cycle arrest. The aim of our study is to investigate the effect of PEE as a cancer chemopreventive agent on 7,12-dimethylbenz[a]nthracene (DMBA)-induced rats mammary. The antiproliferative activity was characterized by monitoring the histopatology representation and expression of cell proliferation on DMBA-induced mammary rats that were treated with PEE against control groups. The histopatology representation were analyzed by Haematoksilin Eosin (HE) staining method, while proliferative activity was detected by AgNOR method. The HE staining results showed significant differences in cells morphology of treatment groups compared to the control groups. Thus results suggest that PEE was able to repair morphology of cells undergoing carcinogenesis. AgNOR method showed decreasing occurrence of black dots between treatment and control groups. Thus, we conclude that PEE has an antiproliferative activity on DMBA-induced rat mammary. Therefore, the ethanolic extract of Physalis angulata herbs is a potential chemopreventive agent on cancer. Further study on its molecular mechanism needs to be explored.Keywords: Physalis angulata, breast cancer, 7,12-dimethylbenz[a]nthracene, carcinogenesis, antiproliferative" @default.
- W2185984975 created "2016-06-24" @default.
- W2185984975 creator A5037955020 @default.
- W2185984975 creator A5045186204 @default.
- W2185984975 creator A5056135054 @default.
- W2185984975 creator A5071363891 @default.
- W2185984975 creator A5084178340 @default.
- W2185984975 date "2011-06-28" @default.
- W2185984975 modified "2023-09-30" @default.
- W2185984975 title "Antiproliferative Activity of Ethanolic Extract of Ciplukan Herbs (Physalis angulata L.) on 7,12-Dimethylbenz[A]Nthracene-Induced Rat Mammary Carcinogenesis" @default.
- W2185984975 cites W1956678452 @default.
- W2185984975 cites W1977814448 @default.
- W2185984975 cites W1999896964 @default.
- W2185984975 cites W2012344721 @default.
- W2185984975 cites W2032845846 @default.
- W2185984975 cites W2106787323 @default.
- W2185984975 cites W2110840243 @default.
- W2185984975 doi "https://doi.org/10.14499/indonesianjcanchemoprev2iss2pp228-233" @default.
- W2185984975 hasPublicationYear "2011" @default.
- W2185984975 type Work @default.
- W2185984975 sameAs 2185984975 @default.
- W2185984975 citedByCount "3" @default.
- W2185984975 countsByYear W21859849752014 @default.
- W2185984975 countsByYear W21859849752021 @default.
- W2185984975 crossrefType "journal-article" @default.
- W2185984975 hasAuthorship W2185984975A5037955020 @default.
- W2185984975 hasAuthorship W2185984975A5045186204 @default.
- W2185984975 hasAuthorship W2185984975A5056135054 @default.
- W2185984975 hasAuthorship W2185984975A5071363891 @default.
- W2185984975 hasAuthorship W2185984975A5084178340 @default.
- W2185984975 hasBestOaLocation W21859849751 @default.
- W2185984975 hasConcept C121608353 @default.
- W2185984975 hasConcept C126322002 @default.
- W2185984975 hasConcept C185592680 @default.
- W2185984975 hasConcept C190283241 @default.
- W2185984975 hasConcept C2776187077 @default.
- W2185984975 hasConcept C2776260934 @default.
- W2185984975 hasConcept C2776984453 @default.
- W2185984975 hasConcept C2778938436 @default.
- W2185984975 hasConcept C530470458 @default.
- W2185984975 hasConcept C55493867 @default.
- W2185984975 hasConcept C555283112 @default.
- W2185984975 hasConcept C556039675 @default.
- W2185984975 hasConcept C62112901 @default.
- W2185984975 hasConcept C71924100 @default.
- W2185984975 hasConcept C86803240 @default.
- W2185984975 hasConceptScore W2185984975C121608353 @default.
- W2185984975 hasConceptScore W2185984975C126322002 @default.
- W2185984975 hasConceptScore W2185984975C185592680 @default.
- W2185984975 hasConceptScore W2185984975C190283241 @default.
- W2185984975 hasConceptScore W2185984975C2776187077 @default.
- W2185984975 hasConceptScore W2185984975C2776260934 @default.
- W2185984975 hasConceptScore W2185984975C2776984453 @default.
- W2185984975 hasConceptScore W2185984975C2778938436 @default.
- W2185984975 hasConceptScore W2185984975C530470458 @default.
- W2185984975 hasConceptScore W2185984975C55493867 @default.
- W2185984975 hasConceptScore W2185984975C555283112 @default.
- W2185984975 hasConceptScore W2185984975C556039675 @default.
- W2185984975 hasConceptScore W2185984975C62112901 @default.
- W2185984975 hasConceptScore W2185984975C71924100 @default.
- W2185984975 hasConceptScore W2185984975C86803240 @default.
- W2185984975 hasIssue "2" @default.
- W2185984975 hasLocation W21859849751 @default.
- W2185984975 hasLocation W21859849752 @default.
- W2185984975 hasOpenAccess W2185984975 @default.
- W2185984975 hasPrimaryLocation W21859849751 @default.
- W2185984975 hasRelatedWork W1827106366 @default.
- W2185984975 hasRelatedWork W2018252982 @default.
- W2185984975 hasRelatedWork W2029177936 @default.
- W2185984975 hasRelatedWork W2150109765 @default.
- W2185984975 hasRelatedWork W2346261729 @default.
- W2185984975 hasRelatedWork W2497245224 @default.
- W2185984975 hasRelatedWork W2610494044 @default.
- W2185984975 hasRelatedWork W2621270776 @default.
- W2185984975 hasRelatedWork W2625065307 @default.
- W2185984975 hasRelatedWork W2741005915 @default.
- W2185984975 hasRelatedWork W2787752679 @default.
- W2185984975 hasRelatedWork W2797905205 @default.
- W2185984975 hasRelatedWork W2945845659 @default.
- W2185984975 hasRelatedWork W2996605498 @default.
- W2185984975 hasRelatedWork W3047123792 @default.
- W2185984975 hasRelatedWork W3108401825 @default.
- W2185984975 hasRelatedWork W3112986182 @default.
- W2185984975 hasRelatedWork W3114265118 @default.
- W2185984975 hasRelatedWork W3152494395 @default.
- W2185984975 hasRelatedWork W3158455433 @default.
- W2185984975 hasVolume "2" @default.
- W2185984975 isParatext "false" @default.
- W2185984975 isRetracted "false" @default.
- W2185984975 magId "2185984975" @default.
- W2185984975 workType "article" @default.