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- W2185989694 abstract "MATERIALS AND METHODS: Forty-five GBM and 21 solitary metastases were retrospectively identified, with their preoperative routine MR imaging analyzed. According to the comparison of the area of peritumoral T2 prolongation with that of the lesion, the tumors were classified into grade I (prolongation area tumor area) and grade II (prolongation area tumor area). The signal intensities of peritumoral T2 prolongation were measured on T2WI and normalized to the values of the contralateral normal regions by calculating the ratios. The ratio (nSI) of both types of tumors was compared in grade I, grade II, and in tumors without grading. The best cutoff values to optimize the sensitivity and specificity were determined for optimal differentiation. RESULTS: The nSI of GBM was significantly higher than that of MET without T2 prolongation grading (P .001), resulting in AUC 0.725. The difference was significant (P .014) in grade I tumors (GBM, 38; MET, 9), with AUC 0.741, and in grade II tumors (GBM, 7; MET, 12), with AUC 0.869 (P .017). Both types of tumors showed a different propensity in T2 prolongation grading ( 2 12.079, P .001). CONCLUSIONS: Combined with qualitative and quantitative analysis of peritumoral T2 prolongation, routine MR imaging can help in the differentiation between brain GBM and solitary MET. ABBREVIATIONS: AUC area under the ROC curve; GBM glioblastoma multiforme; MET metastasis; nSI normalized signal intensity; ROC receiver operating characteristic; WHO World Health Organization" @default.
- W2185989694 created "2016-06-24" @default.
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- W2185989694 date "2012-01-01" @default.
- W2185989694 modified "2023-09-22" @default.
- W2185989694 title "ORIGINAL RESEARCH Differentiation between Brain Glioblastoma Multiforme and Solitary Metastasis: Qualitative and Quantitative Analysis Based on Routine MR Imaging" @default.
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