Matches in SemOpenAlex for { <https://semopenalex.org/work/W2186012159> ?p ?o ?g. }
- W2186012159 abstract "Bile acids are steroidal amphipathic molecules derived from the catabolism of cholesterol. They modulate bile flow and lipid secretion, are essential for the absorption of dietary fats and vitamins, and have been implicated in the regulation of all the key enzymes involved in cholesterol homeostasis. Bile acids recirculate through the liver, bile ducts, small intestine and portal vein to form an enterohepatic circuit. They exist as anions at physiological pH and, consequently, require a carrier for transport across the membranes of the enterohepatic tissues. Individual bile acid carriers have now been cloned from several species. Na + -dependent transporters that mediate uptake into hepatocytes and reabsorption from the intestine and biliary epithelium and an ATP-dependent transporter that pumps bile acids into bile comprise the classes of transporter that are specific for bile acids. In addition, at least four human and five rat genes that code for Na + -independent organic anion carriers with broad multi-substrate specificities that include bile acids have been discovered. Studies concerning the regulation of these carriers have permitted identification of molecular signals that dictate eventual changes in the uptake or excretion of bile acids, which in turn have profound physiological implications. This overview summarizes and compares all known bile acid transporters and highlights findings that have identified diseases linked to molecular defects in these carriers. Recent advances that have fostered a more complete appreciation for the elaborate disposition of bile acids in humans are emphasized. Summary" @default.
- W2186012159 created "2016-06-24" @default.
- W2186012159 creator A5035255859 @default.
- W2186012159 creator A5062829076 @default.
- W2186012159 creator A5073680043 @default.
- W2186012159 creator A5089543992 @default.
- W2186012159 date "2001-01-01" @default.
- W2186012159 modified "2023-10-18" @default.
- W2186012159 title "REVIEW TRANSPORT OF BILE ACIDS IN HEPATIC AND NON-HEPATIC TISSUES" @default.
- W2186012159 cites W119204785 @default.
- W2186012159 cites W1523695341 @default.
- W2186012159 cites W1529891037 @default.
- W2186012159 cites W1532838319 @default.
- W2186012159 cites W1557519226 @default.
- W2186012159 cites W1564537703 @default.
- W2186012159 cites W1580386589 @default.
- W2186012159 cites W1590993351 @default.
- W2186012159 cites W1599316725 @default.
- W2186012159 cites W1600065401 @default.
- W2186012159 cites W1635558573 @default.
- W2186012159 cites W168660332 @default.
- W2186012159 cites W1751582566 @default.
- W2186012159 cites W1751757376 @default.
- W2186012159 cites W1788032165 @default.
- W2186012159 cites W1790911628 @default.
- W2186012159 cites W1828402659 @default.
- W2186012159 cites W1835860051 @default.
- W2186012159 cites W1848455019 @default.
- W2186012159 cites W1853996063 @default.
- W2186012159 cites W1859354720 @default.
- W2186012159 cites W1866641948 @default.
- W2186012159 cites W1882050418 @default.
- W2186012159 cites W1886191257 @default.
- W2186012159 cites W1894354685 @default.
- W2186012159 cites W1895895933 @default.
- W2186012159 cites W1911655428 @default.
- W2186012159 cites W1938519122 @default.
- W2186012159 cites W1950608351 @default.
- W2186012159 cites W1968288625 @default.
- W2186012159 cites W1968320356 @default.
- W2186012159 cites W1968536438 @default.
- W2186012159 cites W1969880653 @default.
- W2186012159 cites W1970999561 @default.
- W2186012159 cites W1976416615 @default.
- W2186012159 cites W1978017146 @default.
- W2186012159 cites W1978412289 @default.
- W2186012159 cites W1979656599 @default.
- W2186012159 cites W1993689132 @default.
- W2186012159 cites W1996402420 @default.
- W2186012159 cites W1998275215 @default.
- W2186012159 cites W1999720909 @default.
- W2186012159 cites W2001647570 @default.
- W2186012159 cites W2002667678 @default.
- W2186012159 cites W2004320689 @default.
- W2186012159 cites W2004367786 @default.
- W2186012159 cites W2007043808 @default.
- W2186012159 cites W2009953980 @default.
- W2186012159 cites W2010623159 @default.
- W2186012159 cites W2012021913 @default.
- W2186012159 cites W2012334383 @default.
- W2186012159 cites W2013019095 @default.
- W2186012159 cites W2013870444 @default.
- W2186012159 cites W2014953943 @default.
- W2186012159 cites W2020789652 @default.
- W2186012159 cites W2021639876 @default.
- W2186012159 cites W2022264886 @default.
- W2186012159 cites W2022972067 @default.
- W2186012159 cites W2023431257 @default.
- W2186012159 cites W2027589960 @default.
- W2186012159 cites W2030438923 @default.
- W2186012159 cites W2030542269 @default.
- W2186012159 cites W2031595392 @default.
- W2186012159 cites W2032033638 @default.
- W2186012159 cites W2034438347 @default.
- W2186012159 cites W2037297309 @default.
- W2186012159 cites W2040417680 @default.
- W2186012159 cites W2040822561 @default.
- W2186012159 cites W2041330339 @default.
- W2186012159 cites W2045580207 @default.
- W2186012159 cites W2045642102 @default.
- W2186012159 cites W2045875385 @default.
- W2186012159 cites W2046831425 @default.
- W2186012159 cites W2047099953 @default.
- W2186012159 cites W2048593300 @default.
- W2186012159 cites W2052812332 @default.
- W2186012159 cites W2053581007 @default.
- W2186012159 cites W2053706150 @default.
- W2186012159 cites W2055745286 @default.
- W2186012159 cites W2058763138 @default.
- W2186012159 cites W2061554663 @default.
- W2186012159 cites W2061569374 @default.
- W2186012159 cites W2062374376 @default.
- W2186012159 cites W2066353982 @default.
- W2186012159 cites W2067603487 @default.
- W2186012159 cites W2067650742 @default.
- W2186012159 cites W2068115199 @default.
- W2186012159 cites W2068458442 @default.
- W2186012159 cites W2068734261 @default.
- W2186012159 cites W2071101614 @default.
- W2186012159 cites W2079058439 @default.