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- W2186014992 abstract "Summary The leaves of khat (Catha edulis) are found to have stimulating and pleasurable effect. The stimulating and insomnial effect is counteracted by ethanol intake. The concomitant use of khat and ethanol ingestion is increasing at an alarming rate, in this country. To study the effect of ethanol and khat on total number of Purkinje neurons and volume of cerebellar cortex, animals of postnatal day 6 were used. They were grouped into control, ethanol, khat and combination of khat and ethanol treated animals each group containing 5 pups. They were deeply anesthetized and sacrificed after 30 days of treatment by perfusion with phosphate buffered formaldehyde. The Cavalier principle and physical dissector methods were used to estimate the volume of cerebellar cortex and numerical density of Purkinje neurons, respectively. The total number of Purkinje neurons was computed from these estimates. It was found that the volume of cerebellar cortex as well as the total number of Purkinje neurons of the ethanol treated animals were significantly less than that of the controls and khat treated animals. No statistically significant difference was observed between the controls and khat treated animals. The numerical density and volume fraction of Purkinje neurons of ethanol treated animals were found to be significantly greater than those of control or khat treated animals. In addition, the numerical density and volume fraction of Purkinje neurons were greater in the khat treated rats than in their corresponding controls, but no statistically significant difference was observed. In conclusion, the study depicted that PND 6 is an extremely vulnerable period during which the rat cerebellar Purkinje neurons are particularly susceptible to the effect of high dose of ethanol. Treatment of khat does not significantly change the above mentioned parameters. On the other hand, combination of khat and ethanol killed all the animals." @default.
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- W2186014992 date "2007-01-01" @default.
- W2186014992 modified "2023-09-27" @default.
- W2186014992 title "DOES INTAKE OF ETHANOL AND KHAT (CATHA EDULIS FORSK) AFFECT THE TOTAL NUMBER OF PURKINJE NEURONS IN EARLY POSTNATAL RATS" @default.
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