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• W2186019726 abstract "Numerous “antihistamines” as well as various psychotropic medications with antihistamine properties are widely utilized to treat insomnia. Over-the-counter sleep aids usually contain an antihistamine and various antidepressants and antipsychotics with antihistamine properties have sedative-hypnotic actions. Although widely used for the treatment of insomnia, many agents that block the histamine H 1 receptor are also widely considered to have therapeutic limitations, including the development of next-day carryover sedation, as well as problems with chronic use, such as the development of tolerance to sedative-hypnotic actions and weight gain. Although these clinical actions are classically attributed to blockade of the H 1 receptor, recent findings with H 1 selective agents and H 1 selective dosing of older agents are challenging these notions and suggest that some of the clinical limitations of current H 1 -blocking agents at their currently utilized doses could be attributable to other properties of these drugs, especially to their simultaneous actions on muscarinic, cholinergic, and adrenergic receptors. Selective H 1 antagonism is emerging as a novel approach to the treatment of insomnia, without tolerance, weight gain, or the need for the restrictive prescription scheduling required of other hypnotics." @default.
• W2186019726 created "2016-06-24" @default.
• W2186019726 creator A5015501263 @default.
• W2186019726 date "2008-12-01" @default.
• W2186019726 modified "2023-09-27" @default.
• W2186019726 title "Selective Histamine H₁ Antagonism: <i>Novel Hypnotic and Pharmacologic Actions Challenge Classical Notions of Antihistamines</i>" @default.
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• W2186019726 doi "https://doi.org/10.1017/s1092852900017089" @default.
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