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- W2186037390 abstract "Solubility is an important physicochemical factor affecting absorption of drug and it’s therapeutic effectiveness. The present research work is to improve the solubility and dissolution rate of olmesartan medoxomil by complexation with HP β-Cyclodextrins. The inclusion complexes were prepared by lyophilization and solvent evaporation method. The prepared complexes were characterized by scanning electron microscopy (SEM) and by X-Ray Diffractometry. The XRD spectra of olmesartan/ hydroxylpropyl βCyclodextrins solid complexes showed that olmesartan medoxomil could form inclusion complex with hydroxylpropyl β-Cyclodextrins in solid state. From the prepared inclusion complexes, fast dissolving tablets were formulated by using superdisintegrants like calcium silicate and sodium starch glycolate in various concentrations. Prepared tablets were evaluated for physical parameters and drug release by in vitro dissolution studies. Complexation of olmesartan medoxomil with hydroxylpropyl β-Cyclodextrins significantly improved the solubility of the drug, drug dissolution speed, improved the mechanical properties of tablets produced by direct compression. Stevia as sweetener has good mouth feeling property help to change perception of medication as bitter pill particularly in geriatric patients." @default.
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- W2186037390 date "2014-01-01" @default.
- W2186037390 modified "2023-09-27" @default.
- W2186037390 title "FORMULATION OF OLMESARTAN FAST DISSOLVING TABLETS USING STEVIA AS SWEETNER" @default.
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