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• W2186038950 abstract "2 Abstract: Damsissa ethanol extract was prepared and dissolved in tween 80 and distilled. Water to obtain 20% suspension for use. Phytochemical screening was carried out according to the prescribed methods. Biological assays were done for detection of estrogen-like activity of the extract using 28 immature female mice (10-13g b. wt.) divided into 4 groups (n=7), the first group was given olive oil(Control group) s/c in a dose of 0.1ml/kg b.wt. for 7days.The 2 group (Standard group) was given estradiol monobenzoate daily by s/c nd injection in a dose of 0.4ug/kg b.wt. for 7 days. The 3 and the 4 groups were treated with damsissa ethanol rd th extract orally in a dose of 5 and 10mg/10 g, b. wt., respectively, daily for 7days. At the end of experiment the mice were weighed then they were sacrificed and their uteri were dissected and weighed. In vivo study was carried out on virgin rabbits. Thirty immature rabbits (1-1.2 kg b. wt.) were divided into three groups (10 rabbits/group). The first group was given 0.1 ml/ kg. b.wt. olive oil subcutaneously daily for 30 days (Control group). The second group (Standard group) was given 0.4 µg / kg. b.wt. oestradiol monobenzoate daily by s/c administration for 30 days. The third group was given 800mg/kg. b.wt. damsissa ethanol extract orally for the same period. The blood samples were taken from the ear vein before treatment and at the end of experimental period blood samples were used for determination of hemogram and serum samples for hormonal assay. The animals were slaughtered at 30 days of experiment and the ovaries and uteri were dissected out and th weighed. The oocytes were collected from the ovarian follicles and cultured in vitro for maturation under conditioned environment for 24 hrs. Phytochemical screening of active constituents of damssisa ethanol extract contain carbohydrates and / or glycosides, flavonoids, tannins, steroids and / or triterpenoids, alkaloids and resins. The tested extract produced significant oestrogen-like activity with various degrees according to the given dose, with lower significant (p < 0.05) in a dose of 50mg/100gm b.wt. and higher significant (p < 0.01) in a dose of 100mg/100gm b.wt. In rabbits, damssisa (400mg/kg.b.wt.) produced significant oestrogen-like activities (p<0.05) in the form of increased both uterine and ovarian weights as compared to the control group. Histopathological examination of the Ovaries and uteri of rabbits from group treated with damsissa extract revealed degenerated corpora lutea and interstitial fibrosis in the ovaries and congestion of stromal blood capillaries in the uterus." @default.
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• W2186038950 date "2014-01-01" @default.
• W2186038950 modified "2023-09-27" @default.
• W2186038950 title "Phytoestrogen Effect of Ambrosia maritima (Damsissa) on the Ovarian Activity of Immature Rabbits" @default.
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