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• W2186042017 abstract "Introduction: The aim of study was to assess a maternal plasma free fetal DNA as a possible predictive factor of hypertensive disorders in pregnancy. Material and methods: A case control study was carried out in the Division of Reproduction, Poznan University of Medical Sciences between October 2006 and October 2007. Plasma samples were obtained from 45 patients in the median 18. weeks of gestation (min. 15, max. 22). We have received information from 19 patients during follow-up. Pregnancies complicated by hypertensive disorders (n = 5) were compared to controls (n = 14). DNA has been extracted and real-time quantitative PCR has been applied for the SRY (Sex-determining Region Y) gene. Free fetal DNA plasma concentration has been counted as genome equivalent. Results: Free fetal DNA maternal plasma concentration was significantly higher in the study group then in the control one. Median genome equivalents was 3.185 in the study group and 0.595 in the control one (p = 0.001). There were no statistically significant differences in occurrence of oedemas or proteinuria, gestational age at delivery, the way of delivery, birth weight and Apgar score between study and control group. Conclusions: Our results confirm ffDNA elevated concentrations in maternal plasma before any symptoms of hypertension disorders in early pregnancy." @default.
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• W2186042017 date "2009-01-01" @default.
• W2186042017 modified "2023-09-27" @default.
• W2186042017 title "Free fetal DNA maternal plasma concentration as predictive factor of hypertensive disorders in pregnancy" @default.
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