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- W2186042832 abstract "Majority of the problems in treating Tuberculosis (TB) is the appearance of drug resistant TB strains, including strains with multiple drug resistance (MDR) and more recently, strains with extensive drug resistance (XDR). From the various MDR mechanisms, main focus is on efflux pumps as they contribute to MDR of Mycobacterium tuberculosis (MTB) in most of the cases. Efflux pumps are transmembrane proteins which actively take part in transporting wide range of substrates including the anti-TB drugs from cytoplasm to exterior of cell, thereby nullifying the drug activity. Efflux pumps are classified in five families based on the energy source they require; that may be ATP driven transporter belonging to ATP-binding cassette (ABC) family or proton driven antiporter belonging to Major facilitator superfamily (MFS), Small multidrug resistance (SMR), Resistancenodulation-cell division (RND) and Multidrug and toxic compounds extrusion (MATE) secondary active transporter. Efflux pumps of these families impart resistance to broad range of antibiotics like fluoroquinolone, tetracycline, ofloxacin, and isoniazid. Taken together, drug efflux pumps prove to be a major challenge for the scientific community and also the focus of this review. Thus, they require special attention to understand their functioning to combat the emerging crisis of MDR and finding a better solution for anti -TB therapy." @default.
- W2186042832 created "2016-06-24" @default.
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- W2186042832 date "2014-01-01" @default.
- W2186042832 modified "2023-09-27" @default.
- W2186042832 title "Efflux pumps in drug resistance of Mycobacterium tuberculosis: A panoramic view" @default.
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