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- W2186043758 endingPage "4819" @default.
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- W2186043758 abstract "Sonic hedgehog (Shh) is a key signal in the specification of ventral cell identities along the length of the developing vertebrate neural tube. In the presumptive hindbrain and spinal cord, dorsal development is largely Shh independent. By contrast, we show that Shh is required for cyclin D1 expression and the subsequent growth of both ventral and dorsal regions of the diencephalon and midbrain in early somite-stage mouse embryos. We propose that a Shh-dependent signaling relay regulates proliferation and survival of dorsal cell populations in the diencephalon and midbrain. We present evidence that Fgf15 shows Shh-dependent expression in the diencephalon and may participate in this interaction, at least in part, by regulating the ability of dorsal neural precursors to respond to dorsally secreted Wnt mitogens." @default.
- W2186043758 created "2016-06-24" @default.
- W2186043758 creator A5003394161 @default.
- W2186043758 creator A5033066969 @default.
- W2186043758 date "2002-10-15" @default.
- W2186043758 modified "2023-10-06" @default.
- W2186043758 title "A sonic hedgehog-dependent signaling relay regulates growth of diencephalic and mesencephalic primordia in the early mouse embryo" @default.
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- W2186043758 doi "https://doi.org/10.1242/dev.129.20.4807" @default.
- W2186043758 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12361972" @default.
- W2186043758 hasPublicationYear "2002" @default.
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