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- W2186047591 abstract "High risk human papillomaviruses (HPV) are known to be the etiological agents of cervical cancer disease, but other cofactors are considered to be important in cervix carcinogenesis. In order to evaluate the role of Epstein-Barr Virus (EBV) and Chlamydia trachomatis infections in cervical carcinogenesis, cervical smears collected in liquid cytology medium from 32 women (29–55 years old) were investigated. Total genomic DNAs (High Pure PCR Template, Roche) and RNA (RNAEasy Mini Kit, Qiagen) were isolated from scrape specimens from patients with different citology (normal cervical epithelium, ASCUS, LGSIL and HGSIL). Total DNAs were tested for HPV DNA presence (Linear Array HPV Genotyping Test, Roche) and C. trachomatis DNA presence (Chlamydia trachomatis Real-TM kit, Sacace Biotechnologies). To elucidate a causative role of EBV in cervical lesions, EBNA1, LMP1 and BZLF1 mRNA gene expression were performed using TaqMan Real Time PCR assays (Applied Biosystems). Our results showed a low incidence of C. trachomatis infection, only 2 cases of NILM presenting C. trachomatis DNA. EBNA1 and BZLF1 expression were relatively high in most cases suggesting a possible role of EBV in cervical lesion progression. HPV DNA was detected in 22.3% of NILM, 33.3% of ASCUS, 75% of LGSIL and 77.8% of HGSIL cases, demonstating the high frequency of HPV infection. Therefore, we suggest that EBV may play a role in cervical precursor lesions but the mechanism of carcinogenesis remains to be further investigated." @default.
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- W2186047591 date "2009-01-01" @default.
- W2186047591 modified "2023-09-27" @default.
- W2186047591 title "EPSTEIN-BARR VIRUS AND CHLAMYDIA TRACHOMATIS AS COFACTORS IN CERVICAL CARCINOGENESIS" @default.
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