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• W2186055009 abstract "The hepatoprotective effect of the mixture of leaves powder of the medicinal plant; Capparis spinosa and honey against some biochemical and histological alterations induced in Swiss albino mice intoxicated with trichloroacetic acid (TCA) was investigated. 120 male mice 20-26gm were divided into 6 groups. Group I was the control group; group II treated orally with honey (40 mg/kg body weight for 3 weeks), group III treated orally with a mixture of Capparis spinosa leaves powder and honey(40 mg/kg for 3 weeks), group IV Given orally aqueous extract of Capparis spinosa leaves powder for 3 weeks, group V treated with TCA in drinking water (500mg/kg for 3 and 6 weeks, then left for 3 weeks for recovery and group VI (Regeneration group) received TCA for 6 weeks then treated with a mixture of Capparis spinosa and honey for 3 weeks. The treatment with TCA for 6 weeks induced 6% deaths in the experimental animals. The mortality increased to 14% in the group left for recovery without treatment whereas, in the group intoxicated with TCA then treated with the mixture of Capparis spinosa and honey the mortality reached 6% only. TCA induced a significant decrease in the final body weight comparing to the control group. Administration of the mixture of Capparis spinosa and honey showed an insignificant increase in the final body weight comparing to TCA alone treated group. Results of the biochemical studies showed abnormal levels of serum enzyme activities in TCA treated animals. Whereas, animals intoxicated with TCA and treated with the mixture of Capparis spinosa and honey showed an improvement in the levels of these serum markers. Histological examination revealed that administration of TCA induced various pathological lesions in liver tissues; included stenosis of hepatic sinusoids, dilatation and congestion of central veins, hemolysis and focal inflammatory cells infiltration, hyperplasia of Kupffer cells, hypertrophied hepatocytes and necrotic hepatocytes with vacuolated cytoplasm were frequently observed. Sever reactivity of most hepatocytes to periodic acid Schiff (PAS) was also noticed. Intoxicated mice treated with the mixture of Capparis spinosa leaves powder and honey showed an improvement in the histological structure. (Aglal A. Alzergy, Saad M.S. Elgharbawy, Ghyath S. Mahmoud and Mervat R. Mahmoud. Role of Capparis spinosa in ameliorating trichloroacetic acid induced toxicity in liver of Swiss albino mice. Life Sci J 2015;12(2):26-39). (ISSN:1097-8135). http://www.lifesciencesite.com. 4" @default.
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• W2186055009 date "2015-01-01" @default.
• W2186055009 modified "2023-09-23" @default.
• W2186055009 title "Role of Capparis spinosa in ameliorating trichloroacetic acid induced toxicity in liver of Swiss albino mice" @default.
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