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- W2186116173 abstract "Methods Samples with 0-2.0mM Gd-DTPA (Magnevist) in water, 1.5, 3.0, and 4.5% bovine serum albumin (BSA, 68kDa, Boehringer, Mannheim), and 5%, 10%, and 20% skim milk (Kroger) were prepared in 0.5mL Eppendorf tubes. Tubes were placed in a holder and immersed in a solution of 0.5mM Gd-DTPA and 0.125M NaCl to minimize susceptibility effects and for appropriate RF coil loading. Images were acquired using wrist phased array coils at 0.7 and 1.5T (GE, Medical), and with single or dual strut TEM coils (8T/80cm Magnex, Bruker). At 0.7 and 1.5T, T1 measurements used IR-FSE with TR/TE=8000/12, ETL=8, and TI ranging from 50 to 4000ms; T2 measurements were obtained using single echo Hahn spin echo sequences with TR=2500ms and TE 11,50,100,250,500ms. At 8T, T1 measurements used IR-SE with TR/TE=4000/12.7ms, and nine TI ranging from 25-3500ms. T2 measurements were obtained with both single echo Hahn and 16-echo CP sequences (TR=2000, TE=12.7-400ms). In all cases, one coronal slice with 3mm thickness and 0.43x0.85mm 2 in-plane resolution was acquired. To minimize detrimental effects from RF inhomogeneity at 8T only 16 samples placed in a 7x7cm 2 area were scanned at once. In addition, B1 field maps were acquired to assess the spatial flip angle variability. Identical samples were used at all field strengths. Data at 0.7T and 8T were acquired on the same day. All data were analyzed by mono-exponential fitting, and relaxivity was determined by linear regression. Results" @default.
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- W2186116173 date "2003-01-01" @default.
- W2186116173 modified "2023-09-27" @default.
- W2186116173 title "Relaxivity of Gd-DTPA in Solution with Different Macromolecular Content at Different Field Strengths from 0.7 to 8.0 Tesla" @default.
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