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- W2186142281 abstract "We consider an exactly tractable model of the Kramers type for the voltage-dependent gating dynamics of single ion channels. It is assumed that the gating dynamics is caused by the thermally activated transitions in a bistable potential. Moreover, the closed state of the channel is highly degenerate and embraces the whole manifold of closed substates. Opening of the ion channel is energetically prohibited from most of the closed substates and requires a special conformation where the voltage sensor can move along an activation pathway and trigger the transition into the open conformation. When the corresponding activation barrier towards the channel’s opening is removed by the applied voltage, the statistics of non-conducting time intervals become strongly in5uenced by the conformational diusion. For the corresponding supra-threshold voltages, our model explain s the originof the power law distributionof the closed time in tervals. The exponential-linear dependence of the opening rate on voltage, often used as an experimental 7t, is also reproduced by our model. c" @default.
- W2186142281 created "2016-06-24" @default.
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- W2186142281 date "2003-01-01" @default.
- W2186142281 modified "2023-09-27" @default.
- W2186142281 title "The role of conformational diusion in ion channel gating" @default.
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