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- W2186151570 abstract "SUMMARY The use of immunosuppressive drugs in rheumatology is fairly recent, having started just after the Second World War with the introduction of the first alkylating agents in oncohematology. When it became clear that some rheumatic diseases, particularly rheumatoid arthritis and systemic lupus erythematosus, show an immunomediated pathogenesis, with aspects of proliferation of the immunocompetent cells, immunosuppressive drugs soon found application in the treatment of such clinical disorders. This review outlines the historical milestones that led to the current use of drugs belonging to major groups of immunosuppressants, i.e., alkylating agents (cyclophosphamide), folic acid (methotrexate) and purine antagonists (azathioprine). Moreover, the history of cyclosporin A, the first immunosuppressant “selective” immunosuppressant agent and that of some immunoactive drugs recently used in rheumatology, such as mycophenolate mofetil, dapsone and thalidomide, is briefly described." @default.
- W2186151570 created "2016-06-24" @default.
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- W2186151570 date "2012-01-01" @default.
- W2186151570 modified "2023-09-26" @default.
- W2186151570 title "Ashorthistoryofanti-rheumatictherapy VIII.Theimmunosuppressants" @default.
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