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- W2186174403 abstract "Thepotency oftheU.S.Reference Smallpox Vaccine, Lot2,theInternational Reference Preparation ofSmallpox Vaccine, andcommercial smallpoxvaccines was determined bythechorioallantoic membrane(CAM)andrabbit scarification (RS) potency assaymethods. Themean titer oftheU.S.Reference (based on 107 ampoules) was 1081pock-forming units (PFU) permlandthatoftheInternational Reference (based on 3ampoules) was 107.8 PFU/ml.A statistical analysis ofthe CAM datafortheU.S.Reference resulted intheestablishment ofa table oflimits ofacceptance forsmallpox vaccines. Ofthecommercial smallpox vaccines tested bytheCAM andRSmethods, 89%demonstrated potencies comparable totheU.S. Reference. Ourresults showthat theCAM test method hasapplication inthecontrol testing ofsmallpox vaccines produced byU.S.licensed manufacturers provided itisusedwithin thelimits discussed. A titration methodforvaccinia virus, based on thenumberofpocks formed on thechorioallantoicmembrane(CAM)oftheembryonated" @default.
- W2186174403 created "2016-06-24" @default.
- W2186174403 creator A5061244626 @default.
- W2186174403 date "1968-01-01" @default.
- W2186174403 modified "2023-09-24" @default.
- W2186174403 title "Comparison ofTitrations on theChorioallantoic Membrane ofChickEmbryos withtheRabbit Scarification Technique forthePotency AssayofSmallpox Vaccines" @default.
- W2186174403 cites W178577150 @default.
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- W2186174403 hasPublicationYear "1968" @default.
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