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- W2186175638 abstract "This paper describes the simple, economic, selective, and precise RP-HPLC method for the simultaneous determination of Metformin, Sitagliptin, Saxagliptin, Linagliptin and Vildagliptin either as single or in combination with each other. The proposed method utilizes Inertsil C18 column (100 mm, 4.6 mm id., 5 µm) and the separation was achieved by using gradient method. Mobile phase-A contains 0.1% Orthophosphoric acid and Mobile phase-B comprised of a mixture of Acetonitrile and Methanol in the ratio of 95:5 v/v, with flow rate of 1.5 mL/min and column temperature was maintained at 40 ° C. Quantitation was achieved with UV detection at 217 nm. The method was linear over wide concentration range of 0.08-0.12 mg/mL for Atenolol, 0.02-0.03 mg/mL for Hydrochlorothiazide, 0.064-0.096 mg/mL for Telmisartan, 0.008-0.012 mg/mL for Amlodipine and 0.08-0.12 mg/mL for Losartan. The method was validated for specificity, linearity, robustness, precision and accuracy. Method is specific for active analyzed as no interference from the blank and excipients were observed at the Retention time of any of the active ingredients. The developed method has an advantage that all the drugs can be quantified alone or in combination using a single mobile phase." @default.
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- W2186175638 date "2014-01-01" @default.
- W2186175638 modified "2023-09-24" @default.
- W2186175638 title "Simultaneous Determination of Metformin, Sitagliptin, Saxagliptin, Linagliptin and Vildagliptin in Multicomponent Pharmaceutical Preparations by RP-HPLC" @default.
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