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- W2186200330 abstract "The work attempts to select and analyse lovastatin from isolated molds of different soil fungi. Lovastatin an inhibitor of 3hydroxy, 3-methylglutaryl coenzyme A reductase (HMG-CoA reductase) enzyme, is a competitive inhibitor of cholesterol biosynthesis. Of the 15 isolates of genus Aspergillus isolated from different soil samples, Aspergillus terreus MTCC 479 strains screened for lovastatin production in submerged fermentation after 7 days of fermentation, all of them showed positive when screened through bioassay method by the zone of inhibition exhibited by the fungus against S.cerevisae. Lovastatin production was further confirmed through the laboratory analytical technique TLC. Colorimetric estimation identified Aspergillus sp. no.76 to be the best producer of lovastatin with a level of 137.5 mg/L. by submerged fermentation. SSF using wheat bran also supported highest lovastatin production by Aspergillus sp. no.76 (18.75 mg/g). High Performance chromatography (HPLC) analysis confirmed that lovastatin from Aspergillus sp. no. 76 has the same retention time with the standard (12.4 minutes)." @default.
- W2186200330 created "2016-06-24" @default.
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- W2186200330 date "2014-01-01" @default.
- W2186200330 modified "2023-09-23" @default.
- W2186200330 title "Bioprospecting of Lovastatin Producing Fungi Isolated from Soil Samples" @default.
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