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- W2186200571 abstract "The incorporation of radioactivity from cytidine-5'- phosphate- ( ~eP)phosphorylethanolamine into 1 -alkyl-2-acyl- sn-glycero-3-phosphorylethanolamines and 1,2-diacyl-sn-glyc- ero-3-phosphorylethanolamines was stimulated more than fourfold by 1-alkyl-2-acyl-sn-glycerols and 1,2-diacyl-sn-glyc- erols, respectively, with an ethanolaminephosphotransferase (EC 2.7.8.1) present in the microsomal fraction from brains of mature rats. The K, values, 0.28 m~ for CDP-ethanolamine and 1.9 mbi for 1 -alkyl-2-acyl-sn-glycerols, were similar to those obtained by other investigators with other 1 -radyl-2- acyl-sn-glycerols. The formation of 1,2-diacyl-sn-glycero-3- phosphorylethanolamines from endogenous 1,2-diacyl-sn-gIyc- erols was inhibited by 1 -alkyl-2-acyl-sn-glycerols. These proper- ties indicate that the ethanolaminephosphotransferase lacks specificity for the type of group at the 1-position of the lipid substrate. The synthesis of l-alkyl-2-acyl-sn-glycero-3-phos- phorylethanolamines from 1 -allcyl-2-acyl-sn-glycerols and CDP- ethanolamine by an enzyme from rat brain supports the in- clusion of this reaction in the metabolic pathway for the syn- thesis of 1 -alk-1 '-enyl-2-acyl-sn-glycero-3-phosphorylethanol- amines." @default.
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- W2186200571 title "microsomal fraction of rat brain" @default.
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