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- W2186201467 abstract "anewandwell tolerated, acid stable macrolide antibiotic, hasasimilar anti- microbial spectrum toerythromycin buta better invitro MIC90(0.03 itg/l-1) against Helicobacter pylon(Hpylori). Thisstudy aimedatdetermining theeradication rate using clarithromycin 500mgthrice daily and omeprazole 40mgdaily fortwoweeks. Patients weregiven anendoscopy andH pylon status assessed byantral culture (microaerobic con- ditions, forupto10days), antral andcorpus histology tests(haematoxylin andeosin/ Gimenezstains), and'3C-urea breath test (13C-UBT, Europeanstandard protocol, positive result=excess b13CO2 excretion >5 permil). Compliance waaassessed byreturned tablet counts. H pylori clearance attheendof treatment anderadication fourweeksafter finishing treatment wereassessed bythe '3C-UBT. Seventy three patients (54men, medianage45years) withduodenal ulcers (n=42)or duodenitis/non-ulcer dyspepsia (n=31) allwitha positive 13C-UBT (mean (SEM)excess&-13C02 excretion=26*6 (4.9) permil) andeither positive antral histology (n=72) orpositive antral culture (n=35) were studied. Before treatment 2/27(7%)isolates ofH pylon wereresistant toclarithromycin andfiveisolates wereresistant tometro- nidazole. In70/73 (96%)the13C-UBT was negative immediately after finishing treatment. Fourweekslater the13C-UBT wasnegative in 57/73 (mean(SEM)excess613C02 excre- tion=1-2 (0.3) permil, eradication rate=78%). Fortyeight (66%)patients experienced a metallic tastewhiletaking thetablets. Although four(5%)patients, however, could notcomplete thecourse oftreatment, inonly oneofthese four wasH pylon noteradicated. Theseresults showthatdueltherapy with clarithromycin andomeprazole iswelltoler- ated. Withaneradication rateof78%itisan effective treatment formetronidazole resistant Hpylon andmaybeanalternative tostandard triple therapy. (Gut 1994; 35:323-326)" @default.
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- W2186201467 date "1994-01-01" @default.
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- W2186201467 title "Eradication ofHelicobacter pylori withclarithromycin andomeprazole" @default.
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