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• W2186203323 abstract "Regulation of apoptosis is an important mechanism during the development of tumors including non-small cell lung cancer (NSCLC). The aim of this study was to assess the relationship between p53 and bcl-2 expression and various clinicopathological features and survival in patients with NSCLC.Histological specimens obtained from 120 patients with stage I-III NSCLC were examined immunohistochemically for p53 and bcl-2.Positive immunostaining for p53 was observed in 50 and for bcl-2 in 35 patients. Tumors with lymph node metastasis were significantly more likely to be bcl-2-positive. However, there was no correlation between p53 immunostaining and clinicopathological parameters. Cox proportional hazard multiple regression analyses identified gender, N status and bcl-2 expression as independent prognostic factors. When advanced stage tumors or tumors with lymph node metastasis were analyzed, a more favorable survival was noted in patients with bcl-2-positive tumors than those with bcl-2-negative tumors.Bcl-2 protein expression correlates with better prognosis in patients with advanced NSCLC." @default.
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• W2186203323 date "2004-07-28" @default.
• W2186203323 modified "2023-09-22" @default.
• W2186203323 title "Bcl-2 protein expression correlates with better prognosis in patients with advanced non-small cell lung cancer." @default.
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