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- W2186203434 abstract "Objective: To assess the clinical and endocrinological efficacy of a combination of spironolactone and oral contraceptive pills in the treatment of hirsutism. Methods: Thirty-six hirsute women were involved in our study; all patients were evaluated clinically and by laboratory investigation before and after six months of treatment with spironolactone (100 mg/day) and Microgynon 30 tables (levonorgestrel 0.15 mg and ethinylestradiol 0.03) from day 5 to day 26 of the cycle. Each patient recorded her subjective assessment of hair growth and any side effects. The results for the group were expressed as means + standard deviation. Results: Out of the 36 patients, 32 completed 6 months of treatment; while 4 patients withdrew from the study due to persistent nausea. Of the 32 patients, 25 had both subjective and objective improvement. Serum level of (testosterone, androstenedione and 17 hydroxyprogesterone) were significantly reduced and sex hormone binding globulin (SHBG) levels were significantly higher after treatment. LH, FSH levels were suppressed in all patients to levels of less than 0.9 i.u/l and less than 0.5 i.u/l after treatment." @default.
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- W2186203434 date "2004-01-01" @default.
- W2186203434 modified "2023-09-26" @default.
- W2186203434 title "USE OF SPIRONOLACTONE IN COMBINATION WITH AN ORAL CONTRACEPTIVE IN TREATMENT OF HIRSUTISM" @default.
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