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• W2186236449 abstract "* These authors are contributed equally to the work. Received June 13, 2013; Accepted June 28, 2013; Epub September 10, 2013; Published September 15, 2013 Abstract: Objective: To determine whether actions on nicotine acetylcholine receptors (nAChRs) contribute to etha- nol's depressant effects on the autonomic nervous system. Methods: The acute effects of ethanol on nAChRs were examined in primary cultured superior cervical ganglion (SCGs) by whole-cell patch clamp recordings. After the whole-cell configuration was formed, drugs diluted to various concentrations with extracellular solution were applied directly to single neurons. Results: Held at -70 mV, ethanol significantly and reversibly inhibited nicotine-evoked currents (I Nic ) with a maximum inhibition rate of ~80% and an IC 50 of 232.88±40.66 mM. At 50 mM, ethanol accel- erated the slow decay, but did not affect the quick decay and rising time of I Nic . There was neither use-dependence nor voltage-dependence of ethanol on suppressing I Nic in SCGs. Conclusion: Ethanol inhibited the whole-cell I Nic sig- nificantly, probably through noncompetitive inhibition at the binding sites outside of the cell membrane." @default.
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• W2186236449 date "2013-01-01" @default.
• W2186236449 modified "2023-09-26" @default.
• W2186236449 title "Original Article Modulation of nicotinic acetylcholine receptors in native sympathetic neurons by ethanol" @default.
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