FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2186268108> ?p ?o ?g. }

• W2186268108 endingPage "140" @default.
• W2186268108 startingPage "132" @default.
• W2186268108 abstract "DBS of the medial forebrain bundle (MFB) has been investigated clinically in major depressive disorder patients with rapid and long-term reduction of symptoms. In the context of chronic bilateral high frequency deep brain stimulation (DBS) of the MFB, the current study looked at the impact of lesioning the ascending dopaminergic pathway at the level of the ventral tegmental area (VTA). Sprague-Dawley female rats were given bilateral injection of 6-OHDA into the VTA (VTA-lx group) or were left unlesioned (control group). Later, all animals received bilateral microelectrode implantation into the MFB followed by chronic continuous stimulation for 3 weeks. Behavioral tests were performed as baseline and following MFB-DBS, along with histological analysis. Pre-stimulation baseline testing of the VTA-lx animals indicated depressive-like phenotype in comparison with controls. Response to MFB-DBS varied according to (i) the degree of dopaminergic depletion: animals with severe mesocorticolimbic dopamine depletion did not, whilst those with mild dopamine loss responded well to stimulation; (ii) environmental conditions and the nature of the behavioral tests, e.g., stressful vs non-stressful situations. Neuromodulation-induced c-fos expression in the prelimbic frontal cortex and nucleus accumbens was also dependent upon integrity of the dopaminergic ascending projections. Our results confirm a potential role for dopamine in symptom relief observed in clinical MFB-DBS. Although mechanisms are not fully understood, the data suggests that the rescue of depressive phenotype in rodents can work via both dopamine-dependent and independent mechanisms. Further investigations concerning the network of depression using neuromodulation platforms in animal models might give insight into genesis and treatment of major depression disorder." @default.
• W2186268108 created "2016-06-24" @default.
• W2186268108 creator A5058565117 @default.
• W2186268108 creator A5069297480 @default.
• W2186268108 creator A5086343420 @default.
• W2186268108 date "2016-02-01" @default.
• W2186268108 modified "2023-10-17" @default.
• W2186268108 title "Ventral tegmental area dopaminergic lesion-induced depressive phenotype in the rat is reversed by deep brain stimulation of the medial forebrain bundle" @default.
• W2186268108 cites W1603857261 @default.
• W2186268108 cites W1665095741 @default.
• W2186268108 cites W1968454359 @default.
• W2186268108 cites W1980505353 @default.
• W2186268108 cites W1985623458 @default.
• W2186268108 cites W1986824281 @default.
• W2186268108 cites W1998274826 @default.
• W2186268108 cites W2003402899 @default.
• W2186268108 cites W2008439504 @default.
• W2186268108 cites W2013598219 @default.
• W2186268108 cites W2014786844 @default.
• W2186268108 cites W2020184819 @default.
• W2186268108 cites W2027274005 @default.
• W2186268108 cites W2028293560 @default.
• W2186268108 cites W2030872572 @default.
• W2186268108 cites W2033835343 @default.
• W2186268108 cites W2034728437 @default.
• W2186268108 cites W2037232254 @default.
• W2186268108 cites W2050836998 @default.
• W2186268108 cites W2052011218 @default.
• W2186268108 cites W2053093248 @default.
• W2186268108 cites W2061383747 @default.
• W2186268108 cites W2066457796 @default.
• W2186268108 cites W2071528977 @default.
• W2186268108 cites W2071815275 @default.
• W2186268108 cites W2071965449 @default.
• W2186268108 cites W2072515505 @default.
• W2186268108 cites W2072903948 @default.
• W2186268108 cites W2073259618 @default.
• W2186268108 cites W2079369179 @default.
• W2186268108 cites W2080827489 @default.
• W2186268108 cites W2112092504 @default.
• W2186268108 cites W2112111711 @default.
• W2186268108 cites W2117782909 @default.
• W2186268108 cites W2120569800 @default.
• W2186268108 cites W2124638964 @default.
• W2186268108 cites W2128682567 @default.
• W2186268108 cites W2141095522 @default.
• W2186268108 cites W2144970933 @default.
• W2186268108 cites W2149514160 @default.
• W2186268108 cites W2157849519 @default.
• W2186268108 cites W2161325655 @default.
• W2186268108 cites W2161773156 @default.
• W2186268108 cites W2165897763 @default.
• W2186268108 cites W22872184 @default.
• W2186268108 cites W2777987555 @default.
• W2186268108 cites W4251472959 @default.
• W2186268108 cites W991491732 @default.
• W2186268108 doi "https://doi.org/10.1016/j.bbr.2015.11.036" @default.
• W2186268108 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26657994" @default.
• W2186268108 hasPublicationYear "2016" @default.
• W2186268108 type Work @default.
• W2186268108 sameAs 2186268108 @default.
• W2186268108 citedByCount "29" @default.
• W2186268108 countsByYear W21862681082016 @default.
• W2186268108 countsByYear W21862681082017 @default.
• W2186268108 countsByYear W21862681082018 @default.
• W2186268108 countsByYear W21862681082019 @default.
• W2186268108 countsByYear W21862681082020 @default.
• W2186268108 countsByYear W21862681082021 @default.
• W2186268108 countsByYear W21862681082022 @default.
• W2186268108 countsByYear W21862681082023 @default.
• W2186268108 crossrefType "journal-article" @default.
• W2186268108 hasAuthorship W2186268108A5058565117 @default.
• W2186268108 hasAuthorship W2186268108A5069297480 @default.
• W2186268108 hasAuthorship W2186268108A5086343420 @default.
• W2186268108 hasBestOaLocation W21862681081 @default.
• W2186268108 hasConcept C126322002 @default.
• W2186268108 hasConcept C137183658 @default.
• W2186268108 hasConcept C151730666 @default.
• W2186268108 hasConcept C15744967 @default.
• W2186268108 hasConcept C169760540 @default.
• W2186268108 hasConcept C24998067 @default.
• W2186268108 hasConcept C2776552330 @default.
• W2186268108 hasConcept C2776669363 @default.
• W2186268108 hasConcept C2778542668 @default.
• W2186268108 hasConcept C2778941446 @default.
• W2186268108 hasConcept C2779134260 @default.
• W2186268108 hasConcept C2779343474 @default.
• W2186268108 hasConcept C2779734285 @default.
• W2186268108 hasConcept C2780948874 @default.
• W2186268108 hasConcept C513476851 @default.
• W2186268108 hasConcept C71924100 @default.
• W2186268108 hasConcept C86803240 @default.
• W2186268108 hasConceptScore W2186268108C126322002 @default.
• W2186268108 hasConceptScore W2186268108C137183658 @default.
• W2186268108 hasConceptScore W2186268108C151730666 @default.
• W2186268108 hasConceptScore W2186268108C15744967 @default.
• W2186268108 hasConceptScore W2186268108C169760540 @default.
• W2186268108 hasConceptScore W2186268108C24998067 @default.

• next