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- W2186269233 abstract "Poised for relay or storage of synaptic information, the postsynaptic neuron must assimilate a variety of incoming synaptic signals and then integrate these into shortand long-term responses. Neuronal signals not only regulate the quantal release of transmitters and peptides acutely, but also dictate the form and content of genetic program that the postsynaptic neuron will express. Indeed, the activity-dependent release of neuro transmitters begins a cascade of events, which culminates in postsynaptic changes in gene expression. Upon binding to postsynaptic receptors, a neurotransmitter evokes specific changes in postsynaptic second messenger pathways that ultimately trigger the rapid induction of postsynaptic genes. Many of these rapidly induced genes then feed-forward to activate genetic programs, which are important for neuronal cell function. Such activity dependent changes may underlie complex phenomena, like long-term memory and synaptic plasticity. This review traces our current understanding of activity-regulated gene expression, from model systems in which neuronal activity alters post synaptic gene expression, to receptor systems and second messengers that participate in the induction, and finally to the molecular mechanisms that may mediate these changes at the transcriptional level." @default.
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- W2186269233 date "1993-01-01" @default.
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- W2186269233 title "TRANS SYNAPTIC CONTROL OF GENE EXPRESSION" @default.
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