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- W2186278830 abstract "The objective of this study was to develop a standard operating procedure for the analysis of skin wound healing using histomorphometrical measurements and mathematical data analyses. The mathematical model is derived from observations of normal cutaneous healing in the rabbit. It is designed to allow a simple scoring of the major steps of healing and remodelling. Full-thickness punch biopsies were performed on the skin of the back of New Zealand-white rabbits and healing was analyzed by histopathological examination after 2, 5, 9 and 14 days, using different staining techniques. Histomorphological measurements were also made. The thickness of the epidermis and neo-epidermis were compared. Several indices relative to wound severity and contraction were computed in an attempt to defi ne a global healing index. A remodelling index was calculated based on a colorimetric analysis with Mallory Trichrome staining and hair migration. The changes in index values seemed to correlate with the histopathological analysis. No material fl aws appeared when this model was applied to the natural healing process. This model was developed for scoring and accurate comparative" @default.
- W2186278830 created "2016-06-24" @default.
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- W2186278830 date "2010-01-01" @default.
- W2186278830 modified "2023-10-18" @default.
- W2186278830 title "Cutaneous reepithelialization and wound contraction after Cutaneous reepithelialization and wound contraction after skin biopsies in rabbits: a mathematical model for healing and skin biopsies in rabbits: a mathematical model for healing and remodelling index remodelling index" @default.
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