FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2186291990> ?p ?o ?g. }

• W2186291990 abstract "In systemic sclerosis (SSc), there is no proven treatment to prevent disease progression. In a recent meta-analysis of three randomised controlled trials (RCTs) and six open prospective studies on cyclophosphamide (CYC), no significant changes in lung function were observed. However, CYC is associated with an improvement of Mahler’s dyspnea index, short form-36 (physical and mental domains), and health-related quality of life, contributing to the amelioration of patients’ functional status. Further RCTs on early SSc are needed to assess the real efficacy of CYC in inducing remission and increasing survival. In a previous issue of Arthritis Research & Therapy, Nannini and colleagues [1] addressed the topic by a well-conducted meta-analysis and concluded that cyclophosphamide (CYC) treatment does not induce a statistically significant improvement in lung function in systemic sclerosis (SSc) interstitial lung disease (ILD). This meta-analysis pooled the data from three randomised controlled trials (RCTs) and six observational studies and focused on the changes in pulmonary functional parameters (forced vital capacity [FVC] and diffusing lung capacity for carbon monoxide [DLCO]) of SSc patients treated with CYC for at least 1 year [1]. Such a conclusion sets a negative scenario in which CYC should not be considered as an ‘anchor’ drug for the treatment of SSc and ILD. In SSc, no drug or combination of drugs has been demonstrated to modify disease progression. In both RCTs versus placebo, the trend toward improvement in FVC suggests that the efficacy of CYC on lung function is limited, as also corroborated by a mild effect size (Table 1) [2,3]. This negative opinion may not reflect what is going on in a ‘real life’ scenario, when other efficacy parameters are considered. Actually, the scleroderma lung study group reported, after 12 months, a significant reduction of Mahler’s dyspnea index in CYC-treated patients when compared with placebo (P <0.0001) and a statistically significant amelioration of short form-36 (SF-36) in each domain: mental (P = 0.006), emotional (P = 0.005), general health status (P = 0.003), and vitality (P = 0.009) [4]. Despite the negligible value of effect size for all of these scale domains, minimum clinically important difference (which represents the smallest improvement in the score of a health-related quality of life measurement instrument which patients perceive as beneficial) was significantly higher for all measures in CYC-treated patients [5]. The improvement of dyspnea and reduction of skin thickness may have a favourable effect not only on functional status but also on psychological aspects, as demonstrated by the analysis of each SF-36 domain." @default.
• W2186291990 created "2016-06-24" @default.
• W2186291990 creator A5001572586 @default.
• W2186291990 creator A5014482226 @default.
• W2186291990 creator A5084838808 @default.
• W2186291990 date "2009-01-01" @default.
• W2186291990 modified "2023-09-27" @default.
• W2186291990 title "Editorial Cyclophosphamide in systemic sclerosis: still in search of a 'real life' scenario" @default.
• W2186291990 cites W1989796927 @default.
• W2186291990 cites W2002964817 @default.
• W2186291990 cites W2056364917 @default.
• W2186291990 cites W2094962451 @default.
• W2186291990 cites W2102599668 @default.
• W2186291990 cites W2108348699 @default.
• W2186291990 cites W2131014787 @default.
• W2186291990 cites W2147543851 @default.
• W2186291990 cites W2155239957 @default.
• W2186291990 cites W2474194199 @default.
• W2186291990 hasPublicationYear "2009" @default.
• W2186291990 type Work @default.
• W2186291990 sameAs 2186291990 @default.
• W2186291990 citedByCount "0" @default.
• W2186291990 crossrefType "journal-article" @default.
• W2186291990 hasAuthorship W2186291990A5001572586 @default.
• W2186291990 hasAuthorship W2186291990A5014482226 @default.
• W2186291990 hasAuthorship W2186291990A5084838808 @default.
• W2186291990 hasConcept C126322002 @default.
• W2186291990 hasConcept C142724271 @default.
• W2186291990 hasConcept C16020263 @default.
• W2186291990 hasConcept C165637977 @default.
• W2186291990 hasConcept C168563851 @default.
• W2186291990 hasConcept C204787440 @default.
• W2186291990 hasConcept C27081682 @default.
• W2186291990 hasConcept C2776694085 @default.
• W2186291990 hasConcept C2776755627 @default.
• W2186291990 hasConcept C2777543607 @default.
• W2186291990 hasConcept C2777714996 @default.
• W2186291990 hasConcept C3018587741 @default.
• W2186291990 hasConcept C55520419 @default.
• W2186291990 hasConcept C71924100 @default.
• W2186291990 hasConcept C75603125 @default.
• W2186291990 hasConcept C95190672 @default.
• W2186291990 hasConceptScore W2186291990C126322002 @default.
• W2186291990 hasConceptScore W2186291990C142724271 @default.
• W2186291990 hasConceptScore W2186291990C16020263 @default.
• W2186291990 hasConceptScore W2186291990C165637977 @default.
• W2186291990 hasConceptScore W2186291990C168563851 @default.
• W2186291990 hasConceptScore W2186291990C204787440 @default.
• W2186291990 hasConceptScore W2186291990C27081682 @default.
• W2186291990 hasConceptScore W2186291990C2776694085 @default.
• W2186291990 hasConceptScore W2186291990C2776755627 @default.
• W2186291990 hasConceptScore W2186291990C2777543607 @default.
• W2186291990 hasConceptScore W2186291990C2777714996 @default.
• W2186291990 hasConceptScore W2186291990C3018587741 @default.
• W2186291990 hasConceptScore W2186291990C55520419 @default.
• W2186291990 hasConceptScore W2186291990C71924100 @default.
• W2186291990 hasConceptScore W2186291990C75603125 @default.
• W2186291990 hasConceptScore W2186291990C95190672 @default.
• W2186291990 hasLocation W21862919901 @default.
• W2186291990 hasOpenAccess W2186291990 @default.
• W2186291990 hasPrimaryLocation W21862919901 @default.
• W2186291990 hasRelatedWork W1601207844 @default.
• W2186291990 hasRelatedWork W1629956987 @default.
• W2186291990 hasRelatedWork W1652396225 @default.
• W2186291990 hasRelatedWork W1751652836 @default.
• W2186291990 hasRelatedWork W1965762626 @default.
• W2186291990 hasRelatedWork W2014018301 @default.
• W2186291990 hasRelatedWork W2124884121 @default.
• W2186291990 hasRelatedWork W2142381454 @default.
• W2186291990 hasRelatedWork W2326353486 @default.
• W2186291990 hasRelatedWork W2342389553 @default.
• W2186291990 hasRelatedWork W2574509953 @default.
• W2186291990 hasRelatedWork W2804492408 @default.
• W2186291990 hasRelatedWork W2883486412 @default.
• W2186291990 hasRelatedWork W2900596103 @default.
• W2186291990 hasRelatedWork W3003685759 @default.
• W2186291990 hasRelatedWork W3049652219 @default.
• W2186291990 hasRelatedWork W3086734401 @default.
• W2186291990 hasRelatedWork W3095467939 @default.
• W2186291990 hasRelatedWork W3119934529 @default.
• W2186291990 hasRelatedWork W3140582275 @default.
• W2186291990 isParatext "false" @default.
• W2186291990 isRetracted "false" @default.
• W2186291990 magId "2186291990" @default.
• W2186291990 workType "article" @default.