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• W2186323427 abstract "Platinum (II) complexes are accredited with biological activities. New complexes with thiepane dioxide diamine as ligands, characterized by defined stereochemical features, a flexible 7-membered thiepane moiety and by C2 symmetry, were prepared. The complexes, related to the diamino cyclohexane family of platinum complexes, were soluble in dimethyl sulfoxide with the solvent substituting one chloride ion. These positively-charged complexes were tested against a human carcinoma cell line A431 and its cisplatin-resistant counterpart A431/Pt and were found to show: i) capability in bypassing cisplatin-resistance; ii) cytotoxicity comparable to that of oxaliplatin; iii) lower activity than cisplatin. In both cells lines, (PtCl(DACH)(DMSO)) + was more cytotoxic than oxaliplatin. The best activity was shown by the platinum complexes with ligands which presented C2 symmetry. In the quest for cisplatin (CDDP) analogs with a better toxicity profile and an improved spectrum of activity, a large number of platinum (Pt) derivatives (several thousand) has been synthesized and investigated. The Pt complexes are widely used antitumor drugs. Furthermore, the relevance of CDDP was also recently verified in postoperative administration, since the rate of local and regional control was reported to increase significantly (1)." @default.
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• W2186323427 date "2006-05-01" @default.
• W2186323427 modified "2023-10-14" @default.
• W2186323427 title "Platinum (II) complexes with stereochemically-defined thiepane dioxide diamine ligands as anticancer drugs." @default.
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