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• W2186329069 abstract "Aim: To examine changes in biomarkers expressed in breast tumors in response to patient treatment with the polyamine synthesis inhibitor α- difluoromethylornithine (DFMO). Patients and Methods: The expression of Ki-67 (MIB-1), matrix metalloproteinases (MMP) 2 and 9, urokinase-type plasminogen activator (uPA) were examined by immunohistochemistry in breast tissue specimens (controls: n=15, 13 evaluable, and DFMO group; n=27, 21 evaluable). Apoptosis was evaluated by terminal deoxynucleotidyl transferase dUTP nick-end labeling (TUNEL). Results: Significant increases in apoptosis, MMP- 9 and uPA (tumor) were observed in 7 patients ≥50 years who received DFMO for ≥14 days relative to patients <50" @default.
• W2186329069 created "2016-06-24" @default.
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• W2186329069 date "2010-06-01" @default.
• W2186329069 modified "2023-09-27" @default.
• W2186329069 title "Effects of α-Difluoromethylornithine on Markers of Proliferation, Invasion, and Apoptosis in Breast Cancer" @default.
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