FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2186341657> ?p ?o ?g. }

• W2186341657 endingPage "53" @default.
• W2186341657 startingPage "43" @default.
• W2186341657 abstract "Background: Time-course and concentration- effect experiments with multiple time-points and drug concentrations provide far more valuable information than experiments with just two design-points (treated vs. control), as commonly performed in most microarray studies. Analysis of the data from such complex experiments, however, remains a challenge. Materials and Methods: Here we present a semi-automated method for fitting time profiles and concentration-effect patterns, simultaneously, to gene expression data. The submodels for time-course included exponential increase and decrease models with parameters, such as initial expression level, maximum effect, and rate- constant (or half-time). The submodel for concentration- effect was a 4-parameter Hill model. Results: The method was applied to an Affymetrix HG-U95Av2 dataset consisting of 51 arrays. The specific study focused on the effects of two platinum drugs, cisplatin and oxaliplatin, on A2780 human ovarian carcinoma cells. Replicates were available at most time points and concentrations. Eighteen genes were selected, and after selection, time-course and concentration- effect were modeled simultaneously. Conclusion: Comparisons of model parameters helped to distinguish genes with different expression patterns between the two drug treatments. This overall paradigm can help in understanding the molecular mechanisms of the agents, and the timing of their actions. Microarray-based experiments have been used to study changes in gene expression due to drug treatment as a function of either time or concentration (1-3). Most published data on such experiments tend to have a limited number of design points - often just two, such as before-treatment versus after-treatment or treated versus untreated. However, with improved accuracy and better affordability of the technology, microarray experiments of increasingly complex designs are being conducted. Among these are time-course and concentration-effect experiments that seek to understand response to drugs as functions of time or concentration or" @default.
• W2186341657 created "2016-06-24" @default.
• W2186341657 creator A5005701884 @default.
• W2186341657 creator A5018109959 @default.
• W2186341657 creator A5057261771 @default.
• W2186341657 creator A5070783001 @default.
• W2186341657 creator A5072313730 @default.
• W2186341657 creator A5088972279 @default.
• W2186341657 date "2008-01-01" @default.
• W2186341657 modified "2023-09-27" @default.
• W2186341657 title "Simultaneous modeling of concentration-effect and time-course patterns in gene expression data from microarrays." @default.
• W2186341657 cites W1966701961 @default.
• W2186341657 cites W1969289662 @default.
• W2186341657 cites W1985723491 @default.
• W2186341657 cites W1986025763 @default.
• W2186341657 cites W1992459316 @default.
• W2186341657 cites W2004150291 @default.
• W2186341657 cites W2007684489 @default.
• W2186341657 cites W2022900334 @default.
• W2186341657 cites W2027003585 @default.
• W2186341657 cites W2029485495 @default.
• W2186341657 cites W2038437697 @default.
• W2186341657 cites W2052639424 @default.
• W2186341657 cites W2064533818 @default.
• W2186341657 cites W2068039256 @default.
• W2186341657 cites W2075746486 @default.
• W2186341657 cites W2101934336 @default.
• W2186341657 cites W2108579152 @default.
• W2186341657 cites W2108675631 @default.
• W2186341657 cites W2108728387 @default.
• W2186341657 cites W2120169559 @default.
• W2186341657 cites W2122135124 @default.
• W2186341657 cites W2132585078 @default.
• W2186341657 cites W2135187880 @default.
• W2186341657 cites W2138832911 @default.
• W2186341657 cites W2143400096 @default.
• W2186341657 cites W2148560070 @default.
• W2186341657 cites W2149579404 @default.
• W2186341657 cites W2150926065 @default.
• W2186341657 cites W2154142993 @default.
• W2186341657 cites W2155374811 @default.
• W2186341657 cites W2155724119 @default.
• W2186341657 cites W2157383618 @default.
• W2186341657 cites W2157795344 @default.
• W2186341657 cites W2159578516 @default.
• W2186341657 cites W2160091849 @default.
• W2186341657 cites W2160697532 @default.
• W2186341657 cites W2162213908 @default.
• W2186341657 cites W2163821484 @default.
• W2186341657 cites W2165298438 @default.
• W2186341657 cites W2167194270 @default.
• W2186341657 cites W2170989872 @default.
• W2186341657 cites W2187781999 @default.
• W2186341657 cites W2587502725 @default.
• W2186341657 cites W2096307164 @default.
• W2186341657 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18359979" @default.
• W2186341657 hasPublicationYear "2008" @default.
• W2186341657 type Work @default.
• W2186341657 sameAs 2186341657 @default.
• W2186341657 citedByCount "5" @default.
• W2186341657 countsByYear W21863416572015 @default.
• W2186341657 countsByYear W21863416572018 @default.
• W2186341657 crossrefType "journal-article" @default.
• W2186341657 hasAuthorship W2186341657A5005701884 @default.
• W2186341657 hasAuthorship W2186341657A5018109959 @default.
• W2186341657 hasAuthorship W2186341657A5057261771 @default.
• W2186341657 hasAuthorship W2186341657A5070783001 @default.
• W2186341657 hasAuthorship W2186341657A5072313730 @default.
• W2186341657 hasAuthorship W2186341657A5088972279 @default.
• W2186341657 hasConcept C104317684 @default.
• W2186341657 hasConcept C107038049 @default.
• W2186341657 hasConcept C121608353 @default.
• W2186341657 hasConcept C138885662 @default.
• W2186341657 hasConcept C150194340 @default.
• W2186341657 hasConcept C18431079 @default.
• W2186341657 hasConcept C186836561 @default.
• W2186341657 hasConcept C24361400 @default.
• W2186341657 hasConcept C2779466056 @default.
• W2186341657 hasConcept C2780962732 @default.
• W2186341657 hasConcept C41008148 @default.
• W2186341657 hasConcept C526805850 @default.
• W2186341657 hasConcept C54355233 @default.
• W2186341657 hasConcept C60644358 @default.
• W2186341657 hasConcept C70721500 @default.
• W2186341657 hasConcept C8415881 @default.
• W2186341657 hasConcept C86803240 @default.
• W2186341657 hasConcept C95371953 @default.
• W2186341657 hasConceptScore W2186341657C104317684 @default.
• W2186341657 hasConceptScore W2186341657C107038049 @default.
• W2186341657 hasConceptScore W2186341657C121608353 @default.
• W2186341657 hasConceptScore W2186341657C138885662 @default.
• W2186341657 hasConceptScore W2186341657C150194340 @default.
• W2186341657 hasConceptScore W2186341657C18431079 @default.
• W2186341657 hasConceptScore W2186341657C186836561 @default.
• W2186341657 hasConceptScore W2186341657C24361400 @default.
• W2186341657 hasConceptScore W2186341657C2779466056 @default.
• W2186341657 hasConceptScore W2186341657C2780962732 @default.
• W2186341657 hasConceptScore W2186341657C41008148 @default.

• next