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- W2186348602 abstract "Despite the benign status of uterine leiomyoma, chromosomal abnormalities involving the chromosome 7 have been described, suggesting the existence of tumor suppressor genes in this region. The shrinkage effect of GnRH agonist on leiomyoma is variable and may be related in part to an autonomous growth. The present study examine the association of the shrinkage effect of GnRH agonist treatment on uterine leiomyomas and microsatellite instability (MSI) and loss of hererozygosity (LOH) with D7S471, D7S496, D7S501, D7S515, D7S518 and D7S666 microsatellite marker. Twenty-nine nuliparous women with uterine leiomyomas, aging from 24 to 39 years old, submitted to US study of leiomyoma volume. They were treated with goserelin 3.6 mg every 28 days for 6 months. Twelve patients had leiomyoma reduction £ 36% and the other seventeen had reduction > 36%. All women were submitted to myomectomy. DNA was extracted from tumor paraffin-embedded tissue and matched peripheral blood. The PCR products were submitted to automated sequencer. We didn’t showed any association between MSI and leiomyoma shrinkage. There was a significant association between LOH in D7S515, D7S518 and D7S666 markers and high leiomyoma shrinkage. (Supported by FAPESP 01/14052-5)." @default.
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- W2186348602 date "2005-01-01" @default.
- W2186348602 modified "2023-09-27" @default.
- W2186348602 title "Association of loss of heterozygosity from 7q22 region and shrinkage of uterine leiomyoma treated with GnRH agonist" @default.
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