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• W2186352307 abstract "Introduction Cyclic guanosine monophosphate (cGMP) signaling plays a critical role in physiological homeostatic processes such as smooth muscle tone in vascular and non-vascular tissues, platelet activity, cardiac contractility, renal function and fluid balance, as well as cell growth. The cGMP signaling consists of cGMP-generating guanylyl-cyclases, protein kinases, phosphodiesterases, endopeptidases, ion channel and efflux transporters and hence substances that increase cGMP levels are important targets for the treatment of cardiovascular and non-vascular-related diseases. Studies of the 90’s established endothelium dysfunction as one of the major causes of cardiovascular diseases and therapeutic strategies that benefit NO bioavailability have been applied in clinical medicine extensively. Recently, the basic and clinical studies of cGMP regulation through either activation of particulate guanylyl cyclase (pGC) and soluble guanylyl cyclase (sGC) or inhibition of cyclic nucleotide phosphodiesterase type 5 (PDE5) have resulted in effective therapies for congestive heart failure, pulmonary hypertension, erectile dysfunction and more recently for benign prostatic hyperplasia. This review highlights pharmacological aspects of sGC and pGC activation and PDE5 inhibition in the treatment of cardiovascular (heart failure and pulmonary hypertension) and vascular-related diseases (erectile dysfunction and lower urinary tract symptoms secondary to benign prostatic hyperplasia). Conclusion The discovery of the NO-cGMP pathway revolutionized the comprehension of pathophysiological mechanisms involved on cardiovascular diseases. However, considering the expression “from bench to bedside”, the therapeutic alternatives that target NO-cGMP did not immediately follow the biochemical and pathophysiological revolution since few therapeutic options have been proven effective and released on the market for the treatment of cardiovascular disorders." @default.
• W2186352307 created "2016-06-24" @default.
• W2186352307 creator A5015836787 @default.
• W2186352307 creator A5044158442 @default.
• W2186352307 creator A5066062695 @default.
• W2186352307 date "2014-01-01" @default.
• W2186352307 modified "2023-09-27" @default.
• W2186352307 title "Modulating cGMP levels as therapeutic drug targets in cardiovascular and non-cardiovascular diseases" @default.
• W2186352307 cites W1491435711 @default.
• W2186352307 cites W1520611194 @default.
• W2186352307 cites W1547451879 @default.
• W2186352307 cites W1566921440 @default.
• W2186352307 cites W187159779 @default.
• W2186352307 cites W1931029783 @default.
• W2186352307 cites W1939988054 @default.
• W2186352307 cites W1965507602 @default.
• W2186352307 cites W1967712758 @default.
• W2186352307 cites W1969673967 @default.
• W2186352307 cites W1972029787 @default.
• W2186352307 cites W1975921081 @default.
• W2186352307 cites W1976097176 @default.
• W2186352307 cites W1976585641 @default.
• W2186352307 cites W1978545009 @default.
• W2186352307 cites W1978712206 @default.
• W2186352307 cites W1982601738 @default.
• W2186352307 cites W1983311124 @default.
• W2186352307 cites W1984243104 @default.
• W2186352307 cites W1996204455 @default.
• W2186352307 cites W1997605348 @default.
• W2186352307 cites W1999307079 @default.
• W2186352307 cites W2000866488 @default.
• W2186352307 cites W2004742560 @default.
• W2186352307 cites W2008246208 @default.
• W2186352307 cites W2008560919 @default.
• W2186352307 cites W2012627991 @default.
• W2186352307 cites W2013301189 @default.
• W2186352307 cites W2018377518 @default.
• W2186352307 cites W2021965311 @default.
• W2186352307 cites W2024461582 @default.
• W2186352307 cites W202875810 @default.
• W2186352307 cites W2031965441 @default.
• W2186352307 cites W2036869521 @default.
• W2186352307 cites W2038016226 @default.
• W2186352307 cites W2042260765 @default.
• W2186352307 cites W2042322531 @default.
• W2186352307 cites W2043463661 @default.
• W2186352307 cites W2045866331 @default.
• W2186352307 cites W2050093658 @default.
• W2186352307 cites W2053775321 @default.
• W2186352307 cites W2056147576 @default.
• W2186352307 cites W2056609484 @default.
• W2186352307 cites W2057433961 @default.
• W2186352307 cites W2064959038 @default.
• W2186352307 cites W2065399599 @default.
• W2186352307 cites W2072570077 @default.
• W2186352307 cites W2073978463 @default.
• W2186352307 cites W2074224605 @default.
• W2186352307 cites W2074597824 @default.
• W2186352307 cites W2077147032 @default.
• W2186352307 cites W2077788923 @default.
• W2186352307 cites W2079746444 @default.
• W2186352307 cites W2080512195 @default.
• W2186352307 cites W2082766121 @default.
• W2186352307 cites W2086149837 @default.
• W2186352307 cites W2087957652 @default.
• W2186352307 cites W2090926515 @default.
• W2186352307 cites W2092237225 @default.
• W2186352307 cites W2092247085 @default.
• W2186352307 cites W2093885131 @default.
• W2186352307 cites W2094482821 @default.
• W2186352307 cites W2096587424 @default.
• W2186352307 cites W2101915418 @default.
• W2186352307 cites W2105830583 @default.
• W2186352307 cites W2105851379 @default.
• W2186352307 cites W2106375145 @default.
• W2186352307 cites W2110793872 @default.
• W2186352307 cites W2113748458 @default.
• W2186352307 cites W2113945614 @default.
• W2186352307 cites W2117855679 @default.
• W2186352307 cites W2118706709 @default.
• W2186352307 cites W2125954699 @default.
• W2186352307 cites W2128214844 @default.
• W2186352307 cites W2128641207 @default.
• W2186352307 cites W2133975951 @default.
• W2186352307 cites W2134107567 @default.
• W2186352307 cites W2135521686 @default.
• W2186352307 cites W2137267977 @default.
• W2186352307 cites W2137428544 @default.
• W2186352307 cites W2137470086 @default.
• W2186352307 cites W2137844241 @default.
• W2186352307 cites W2141213305 @default.
• W2186352307 cites W2147939322 @default.
• W2186352307 cites W2149641204 @default.
• W2186352307 cites W2151554163 @default.
• W2186352307 cites W2156477379 @default.
• W2186352307 cites W2158671740 @default.
• W2186352307 cites W2164314627 @default.
• W2186352307 cites W2166027269 @default.
• W2186352307 cites W2167504169 @default.
• W2186352307 cites W2170573973 @default.

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