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- W2186352848 abstract "al ,B-tubulin mutation tub2-150. Thismutation isunique among thehundreds oftubulin mutations isolated inSaccharomyces cerevisiae inthat itappears to causeanincrease inthestability ofmicrotubules. We report herethatthis allele isa mutation ofthreonine 238toalanine, andthattub2-150 prevents thespindle from elongating during anaphase, suggesting anuclear microtubule defect. Toidentify regulators ofmicrotubule stability and/or anaphase, yeast geneswereselected that, when overexpressed, couldsuppress thetub2-150 temperature-sensitive phenotype. Oneof these genes, JSNI, encodes aprotein of125kDathat haslimited similarity toanumber ofproteins ofunknownfunction. Overexpression oftheJSNIgeneinaTUB2strain causes thatstrain tobecomemoresensitive tobenomyl, amicrotubule-destabilizing drug. Ofarepresentative groupofmicrotubule mutants, onlyoneother mutation, tub2-404, could besuppressed byJSNIoverexpression, showing thatJSNIisanallelespecific suppressor. Astub2-404 mutants arealso defective forspindle elongation, this provides additional support forarole forJSNI during anaphase." @default.
- W2186352848 created "2016-06-24" @default.
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- W2186352848 date "1995-01-01" @default.
- W2186352848 modified "2023-09-27" @default.
- W2186352848 title "Microtubule Stability inBudding Yeast: Characterization andDosageSuppression ofa Benomyl-dependent Tubulin Mutant" @default.
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