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- W2186354471 abstract "Know over 2.500 years, affective disorders still present major interest in the public health studies, particularly the major depressive disorder (MDD). Several antidepressant drugs have been developed, including the selective serotonin reuptake inhibitors (SSRI) fluoxetine, the first choice for the MDD drug-therapy. Besides that, Hypericum perforatum (HP) extracts have been more and more prescribed, and are the most used antidepressants in several European countries. This review had, as its objective, to evaluate efficiency and compliance to the treatment of mild to moderated MDD patients: fluoxetine and HP extracts, through studies published from 2005, identified in MEDLINE, Ovid, ScienceDirect databases as well as textbooks. Among these studies, three papers considered HP as more efficient than fluoxetine, one paper had the opposite conclusion and one did not demonstrate any significant difference. The studies that evaluated the tolerance were unanimous about the superiority of HP. HP efficiency in MDD treatment was controversial. All papers revised used one to three doses of HP 900 mg/day and a single fluoxetine 20 mg/day dose. The treatment was carried out for 4-12 weeks, and the patients were diagnosed with mild to moderated MDD. Further studies, including other dosage regimens and long-term treatments, must be carried out in order to provide consistent data on mild or moderated MDD drug-therapy for health professionals involved with the treatment of patients in this clinical condition." @default.
- W2186354471 created "2016-06-24" @default.
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- W2186354471 date "2011-01-01" @default.
- W2186354471 modified "2023-09-27" @default.
- W2186354471 title "Fluoxetina ou Hypericum perforatum no tratamento de pacientes portadores de transtorno depressivo maior leve a moderado? Uma revisão Fluoxetine or Hypericum perforatum to treat mild to moderated major depressive disorder patients? A review" @default.
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