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• W2186359229 abstract "Summary. Coronary patients with diabetes are at high risk of cardiovascular events. Coronary disease in diabetic patients has a rapid and progressive course due to the synergic activity of hyperglycemia and other risk factors of coronary disease such as dyslipidemia, hypertension, obesity, and smoking. Diabetic autonomic neuropathy which first affects the vagal nerves contributes to the bad prognosis of coronary patients with diabetes. The best marker of the state of activity of the autonomic nervous system is heart rate variability, which is a predictor of cardiac mortality. The aim of this study was to determine a possible influence of diabetes mellitus on the left ventricular function and the parameters of heart rate variability, as well as the relation between the left ventricular function and the parameters of heart rate variability in patients after myocardial infarction and diabetes. We studied 141 patients after myocardial infarction in the sinus rhythm without AV blocks or branch blocks. Thirtyfive patients had diabetes mellitus, and 106 did not. The average age of the patients was 58.82 years. Besides clinical examination and laboratory analyses, standard ECG, exercise test on a treadmill according to Bruce protocol, 24hour holter monitoring, and echocardiographic examination were performed in each patient. Based on the holter record, the analysis of the heart rate variability was performed by software. Four parameters of the time domain heart rate variability were assessed: SDNN, SDANN, RMS-SD and NN > 50 ms. Diabetic patients after myocardial infarction had a significantly lower values of the monitored parameters of heart rate variability, compared to those without diabetes (89.47 ± 30.82 vs. 103.28 ± 32.18 ms; p 50 ms). Diabetics also had significantly lower values of LVEF (49.19 ± 8.01 vs. 52.84 ± 11.24 %; p 50 ms did not correlate significantly with LVEF or the internal dimensions of the left ventricle in diabetics after myocardial infarction. The study demonstrated diabetic patients who suffered myocardial infarction have significantly lower values of the parameters of heart rate variability, significantly lower values of LVEF and significantly higher values of LVESd, as well as a higher degree of the left ventricle diastolic dysfunction, compared to non-diabetics. The study showed that there is a significant positive correlation of SDNN and SDANN values with LVEF and a significant negative correlation with LVESd in diabetics who suffered myocardial infarction." @default.
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• W2186359229 date "2005-01-01" @default.
• W2186359229 modified "2023-09-26" @default.
• W2186359229 title "IMPACT OF DIABETES ON HEART RATE VARIABILITY AND LEFT VENTRICULAR FUNCTION IN PATIENTS AFTER MYOCARDIAL INFARCTION" @default.
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