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• W2186361084 startingPage "373" @default.
• W2186361084 abstract "Delivery of macromolecular drugs is an important field in medical research. However, macromolecules are usually unable to cross the cell membrane without the assistance of a delivery system. Cell penetrating peptides (CPPs) are unique tools to gain access to the cell interior and deliver a bioactive cargo into the cytosol or nucleus. In addition to macromolecular delivery, CPPs have been used to deliver smaller bioactive molecules. Therefore CPPs have become an intensive field of research for medical treatment.In this review, we highlight studies that include CPP in vivo disease models. We review different strategies and approaches that have been used, with specific attention on recent publications. The approaches that have been used include CPP-cargo covalent conjugation strategies and nanoparticle strategies. Various additional strategies have been used to achieve disease targeting, including active targeting, passive targeting, and combined active/passive strategies. As a result, delivery of various types of molecule has been achieved, including small drug molecules, proteins and nucleic acid-based macromolecules (e.g. siRNA, antisense nucleotides and plasmid DNA).Despite recent advances in the field, confusions surrounding CPP internalization mechanisms and intracellular trafficking are hindering the development of new and more efficient vectors. Nevertheless, the recent increase in the number of publications containing in vivo CPP utilization looks promising that the number of clinical trials would also increase in the near future." @default.
• W2186361084 created "2016-06-24" @default.
• W2186361084 creator A5032022835 @default.
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• W2186361084 date "2015-12-22" @default.
• W2186361084 modified "2023-09-26" @default.
• W2186361084 title "Recent<i>in vivo</i>advances in cell-penetrating peptide-assisted drug delivery" @default.
• W2186361084 cites W1516421005 @default.
• W2186361084 cites W1585705786 @default.
• W2186361084 cites W1616350046 @default.
• W2186361084 cites W1899761045 @default.
• W2186361084 cites W1964878760 @default.
• W2186361084 cites W1967170977 @default.
• W2186361084 cites W1973317044 @default.
• W2186361084 cites W1975148998 @default.
• W2186361084 cites W1978068894 @default.
• W2186361084 cites W1978498174 @default.
• W2186361084 cites W1981057288 @default.
• W2186361084 cites W1985176970 @default.
• W2186361084 cites W1988313934 @default.
• W2186361084 cites W1992044364 @default.
• W2186361084 cites W1992498787 @default.
• W2186361084 cites W1994941022 @default.
• W2186361084 cites W1996164852 @default.
• W2186361084 cites W1998004849 @default.
• W2186361084 cites W2001051598 @default.
• W2186361084 cites W2001358573 @default.
• W2186361084 cites W2001498530 @default.
• W2186361084 cites W2001582257 @default.
• W2186361084 cites W2007888673 @default.
• W2186361084 cites W2010659535 @default.
• W2186361084 cites W2017543360 @default.
• W2186361084 cites W2019246838 @default.
• W2186361084 cites W2035187804 @default.
• W2186361084 cites W2044730898 @default.
• W2186361084 cites W2046044004 @default.
• W2186361084 cites W2046314109 @default.
• W2186361084 cites W2046962658 @default.
• W2186361084 cites W2052758340 @default.
• W2186361084 cites W2055051767 @default.
• W2186361084 cites W2063212792 @default.
• W2186361084 cites W2070302990 @default.
• W2186361084 cites W2070693578 @default.
• W2186361084 cites W2072554913 @default.
• W2186361084 cites W2073847499 @default.
• W2186361084 cites W2076321231 @default.
• W2186361084 cites W2076324415 @default.
• W2186361084 cites W2081088550 @default.
• W2186361084 cites W2082432974 @default.
• W2186361084 cites W2084621409 @default.
• W2186361084 cites W2084671299 @default.
• W2186361084 cites W2087094217 @default.
• W2186361084 cites W2088422531 @default.
• W2186361084 cites W2089583046 @default.
• W2186361084 cites W2089607331 @default.
• W2186361084 cites W2099132605 @default.
• W2186361084 cites W2103262726 @default.
• W2186361084 cites W2105668301 @default.
• W2186361084 cites W2115824449 @default.
• W2186361084 cites W2117698690 @default.
• W2186361084 cites W2119618139 @default.
• W2186361084 cites W2120085804 @default.
• W2186361084 cites W2120261970 @default.
• W2186361084 cites W2125284587 @default.
• W2186361084 cites W2127677388 @default.
• W2186361084 cites W2130194831 @default.
• W2186361084 cites W2132732108 @default.
• W2186361084 cites W2135286723 @default.
• W2186361084 cites W2142536456 @default.
• W2186361084 cites W2143685793 @default.
• W2186361084 cites W2145057519 @default.
• W2186361084 cites W2155170820 @default.
• W2186361084 cites W2157428889 @default.
• W2186361084 cites W2160863389 @default.
• W2186361084 cites W2161146618 @default.
• W2186361084 cites W2166634853 @default.
• W2186361084 cites W2166961017 @default.
• W2186361084 cites W2170916169 @default.
• W2186361084 cites W2173480191 @default.
• W2186361084 cites W2316856761 @default.
• W2186361084 cites W2337794093 @default.
• W2186361084 cites W2412030977 @default.
• W2186361084 cites W2416285872 @default.
• W2186361084 cites W2466229277 @default.
• W2186361084 doi "https://doi.org/10.1517/17425247.2016.1125879" @default.
• W2186361084 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26634750" @default.
• W2186361084 hasPublicationYear "2015" @default.
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