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- W2186381870 abstract "Tumour suppressor gene, PTEN has been found to be altered in various types of tumours such as breast, glioblastoma, prostate, endometrial cancers and colorectal carcinoma (CRC). Alterations have been found to be common in sporadic colorectal tumours. Our objective was to identify PTEN mutations in colorectal tumours and blood samples from Malaysian patients. We analysed genomic DNA from 27 paired normal and tumour tissue samples and 10 blood samples. Nineteen of these samples were from a previous study that had failed to identify APC and β-catenin gene mutations. Both these genes are involved in early events related to colorectal carcinoma tumorigenesis. The entire coding region and the flanking sites of the 9 exons of PTEN gene was amplified and conformation sensitive gel electrophoresis (CSGE) and sequencing was done to identify alterations. We found no PTEN alterations among the colorectal cancer samples we had examined and thereby conclude that there is a lack of PTEN involvement in the carcinogenesis of colorectal cancer in these patients." @default.
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- W2186381870 date "2007-01-01" @default.
- W2186381870 modified "2023-09-27" @default.
- W2186381870 title "PTEN Mutation Studies In Malaysian Colorectal Cancer Patients" @default.
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