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- W2186397780 abstract "Direct compression is a technique of tablet manufacturing without an intermediate granulating step. It can only be applied for those drug having good micromeritic properties i.e. flowability and compressibility. But for poorly soluble drugs, spherical crystallization technique was developed by Kawashima and their coworkers in 1986. It is a novel particle design technique in which both crystallization and agglomeration carried out simultaneously in single step. This technique is used for size enlargement of drugs which is successfully utilized for improvement of physiochemical and micromeritic of different poorly soluble drugs. Bioavailability and solubility enhancement of pharmaceutical drug is reported by spherical crystallization. In this review we will discuss about the advantage, methods which are applied in spherical crystallization process. In addition, list of all the drugs on which spherical crystallization methods have been performed." @default.
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- W2186397780 date "2013-01-01" @default.
- W2186397780 modified "2023-09-27" @default.
- W2186397780 title "SPHERICAL CRYSTALLIZATION TO IMPROVE PHYSIOCHEMICAL AND MICROMERITIC PROPERTIES: A REVIEW" @default.
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