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- W2186400935 abstract "Ginger (Zingiberofficinale) contains active phenolic compounds that have antioxidant, anti-cancer, anti-inflammatory and antithrombotic properties. The aim of the present study was to evaluate the chemo protective effect of Z. officinale roots against aspartame inducedrat nephrotoxicity. The chosen dose of aspartame was adjusted to 0.2ml/ 25g b.wt. and was given three times per week for 12 weeks. Ginger aqueous extract were adjusted to 500mg/kg and were given three times per week for 12 weeks. Aspartame caused a marked rise in serum urea, creatinine and potassium level which improved by ginger extract pretreatment. Sodium level was decline in aspartame treated group that ameliorated through ginger extract pretreatment. Concerning oxidative stress and antioxidant defense system, ginger extract pretreatment successfully improved renal reduced glutathione (GSH) level, glutathione peroxidation (GPx) and superoxide dismutase (SOD) activities compared to aspartame treated group which give inverse results. However, while elevated lipid peroxidation (MDA) was noticed in aspartame treated rats, pretreatment with ginger extract produced a detectable decrease in lipid peroxidation level. The natural plant components may have chemo preventive effect against aspartame that induce nephrotoxicity and oxidative stress. However, further clinical studies are required to assess the safety and benefits of ginger root in human beings." @default.
- W2186400935 created "2016-06-24" @default.
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- W2186400935 date "2015-01-01" @default.
- W2186400935 modified "2023-09-26" @default.
- W2186400935 title "CHEMOPREVENTIVE EFFECTS OF ZINGIBEROFFICINALEEXTRACT AGAINST ASPARTAME INDUCED NEPHROTOXICITY AND OXIDATIVE STRESS IN RAT MODEL" @default.
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