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• W2186404559 abstract "Diazepam-tolerant but ovariectomized rats were primed with 50 µg oestradiol benzoate and 500 µg progesterone to induce a lordosis quotient of moderate intensity. Enhancing of lordosis was induced by treating with 5-HT 2A/2C receptor agonist, DOI. The effect of the 5-HT 2C receptor antagonist, ketanserin and the 5-HT 2A receptor antagonist, ritanserin, on lordosis behaviour were investigated in ovariectomized but steroids-primed diazepam- tolerant rats. Both ketanserin and ritanserin inhibited lordosis behaviour. A potent protective effect of DOI was noted following antagonists ketanserin and ritanserin treatment. DOI attenuated the lordosis inhibiting effect of ritanserin- injected to diazepam-tolerant rats. These data show that diazepam-tolerance as such did not cause significant change in the lordosis profile. Behavioural profile as a consequence of ritanserin and DOI treatment further reinforce the prior inference that facilitation of female lordosis behaviour is differentially mediated by 5-HT 2 receptor agents and tolerance to anxiolytic does not alter the lordosis profile, significantly." @default.
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• W2186404559 date "2006-01-01" @default.
• W2186404559 modified "2023-09-27" @default.
• W2186404559 title "Facilitation of Lordosis Behaviour is Differentially Mediated by 5-Ht 2 Receptor Agents in Diazepam- Tolerant Female Rats" @default.
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