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• W2186408897 abstract "Aronia melanocarpa (Black chokeberry) has shown a high content of polyphenol compounds and possesses one of the highest antioxidant activities among fruits. On the other hand, the therapeutic value of one of the most effective the chemotherapeutic agents, Doxorubicin (DOX), is limited by its toxicity. Although the mechanisms of this toxicity are not fully elucidated, oxidat ive stress appears to be involved. In this aspect, the current study was directed to investigation on the possible protective effect of the total extract from this medicinal plant against DOX - induced toxicity and oxidative stress in vitro. Despite of the e stablished decrease of the reduced Glutathione (GSH) levels in normal cells and mixed cultures in the presence of Doxorubicin, certain regeneration in them was noticed in the presence of Aronia - extract. Slight differences in cell morphology in the presence of plant extract, expressed mainly in increased size, rounded cell form and changed nuclei/cytoplasm ratio, in comparison with the untreated controls and cells, treated by Doxorubicin alone, were observed. Those changes were accepted as signs for early my eloid differentiation, probably mainly of embryonic stem cell sub - populations from 3T3 cell line . Further studies on the influence of separate plant components on the levels of intracellular GSH would be necessary." @default.
• W2186408897 created "2016-06-24" @default.
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• W2186408897 date "2015-01-01" @default.
• W2186408897 modified "2023-09-27" @default.
• W2186408897 title "Experimental Models for Investigation of Antioxidant and Immunomodulatory Effects in Vitro of Aronia melanocarpa Extract" @default.
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