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- W2186430905 abstract "Proteomics technology offers a conceptually attractive platform for disease biomarker discovery. In protein biomarker discovery phase, some maturely quantitative proteomics methods such as stable isotope labeling by amino acids in cell culture (SILAC), isobaric peptide tags for relative and absolute quantification (iTRAQ), and label-free can be chosen. A common endpoint for a biomarker discovery experiment is a list of putative marker proteins. A reasonable next step is to perform target quantitative measurements of these proteins in an expanded patient population to verify their statistical significance. In addition, developments in quantitative MS, such as multiple reaction monitoring (MRM), have greatly enhanced both the specificity and sensitivity of MS-based assays to the point that they can rival immunoassay for some analytes. It is powerful for a lot of candidates verified. But for clinical diagnosis or monitoring, in general, the target biomarker is less than five proteins, so an immunoassay such as ELISA, Western blot, and antibody microarray is more suitable for the detection." @default.
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- W2186430905 date "2012-12-27" @default.
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- W2186430905 title "Clinical Translation of Protein Biomarkers Integrated with Bioinformatics" @default.
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