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• W2186496997 abstract "A trial fibrillation (AF) is a common arrhythmia, especially in the elderly. Approximately 4% of those older than 60 years and 9% of those older than 80 years have AF. In addition, AF remains a significant complication following cardiac surgery and post heart transplant. The risk of stroke is increased by fourto fivefold in AF patients and AF is responsible for about 16% of all ischaemic strokes in the elderly. This arrhythmia is also associated with a twofold mortality. Over the next decades the number of Americans with non-valvular AF is expected to increase markedly, making AF-related stroke an important public health concern. Recently, both animal and clinical studies have improved our knowledge of the pathogenesis of AF. The pathophysiology of AF is complex, but in most cases it may be caused by multiple random re-entering wavelets. The autonomic nervous system is a potentially potent modulator of the initiation, maintenance, termination and ventricular rate in AF. Hypertension, diabetes mellitus, male gender, age, obesity, metabolic syndrome and coronary artery disease have been identified as risk factors for non-valvular AF. These factors are also major risk factors for vascular disease, which suggests that AF, particularly in older and hypertensive patients, might be part of the atherosclerosis spectrum. Moreover, acute or chronic haemodynamic, metabolic or inflammaAtrial Fibrillation, Inflammation and Statins EMMANUEL S. GANOTAKIS, DIMITRI P. MIKHAILIDIS, PANOS E. VARDAS Departments of Internal Medicine and Cardiology, Heraklion University Hospital, Crete, Greece; Department of Clinical Biochemistry (Vascular Disease Prevention Clinics), Royal Free Hospital, Royal Free and University College Medical School, London, UK" @default.
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• W2186496997 date "2006-06-07" @default.
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• W2186496997 title "Atrial fibrillation, inflammation and statins." @default.
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