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- W2186514909 abstract "AIM: To assess efficacy of inhaled nitric oxide (iNO) in postoperative cases of congenital heart defects who developed critical pulmonary hypertension and had no response to conventional pulmonary vasodilator. METHODS: From January 1997 to May 2002, 37 patients, age ranging 14 days to 14 years and body weight 3.1 to 32 kg, were enrolled in the iNO therapy. Indication for iNO: ratio of pulmonary to systemic systolic arterial pressure (Pp/Ps)> 0.5, ratio of arterial oxygen tension to fraction of inspired oxygen (PaO2/FiO2) 0.05), whereas PaO2/FiO2 increased from 106.6±36.8 to 176.5±66.0 (P<0.01). Thirty four patients discharged at (5.5±5.4) d (range 2-18 d) and 3 died. Inhaled nitrogen dioxide was less than 1 ppm and methemoglobin less than 2 %. No hemorrhage and other adverse effects were observed. CONCLUSION: iNO improved pulmonary hemodynamics and blood oxygenation in postoperative critical pulmonary hypertension without adverse effects." @default.
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- W2186514909 date "2002-01-01" @default.
- W2186514909 modified "2023-09-23" @default.
- W2186514909 title "Inhalation of nitric oxide in congenital heart defects associated with pulmonary hypertension 1" @default.
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