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- W2186530519 abstract "The etiology and pathogenesis of ulcerative colitis (UC) have remained unclear. Treatment is nonspecific based on the anti- inflammatory agents corticosteroid and sulfasalazine. A significant proportion fail to respond to this therapy[1]. As the relapse, refractory or serious UC patients had a hypercoagulable state and an increased incidence of thromboembolic events[2-4], heparin has been used by some authors[5-7]. Yet, its half-life period is short, needing long-term injection, which restricts its further clinical application. Our previous studies have demonstrated oral LMWH not only overcomes the shortcomings of common heparin[8,9], but also has anti-inflammatory effects[10,11]. The aim of this paper is to study the therapeutic effects and mechanism of oral LMWH in patients with corticosteroid-resistant UC." @default.
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- W2186530519 date "1999-01-01" @default.
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- W2186530519 title "Treatment of corticosteroid-resistant ulcerative colitis with oral low molecular weight heparin" @default.
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- W2186530519 doi "https://doi.org/10.3748/wjg.v5.i5.448" @default.
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