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• W2186534744 abstract "In experimentally induced hyperkeratosis, remarkable changes in the composition of free amino acids were observed in the stratum comeurn. The metabolites, pyrrolidone carboxylic acid, urocanic acid, citrulline, and alanine, are believed to have been formed from glutamic acid, histidine, ornithine, and aspartic acid, respectively, at the final stage of keratin formation. The rates of conversion to these amino acid metabolites greatly decreased in hyperkeratosis. Accordingly, the conversion rates can be useful parameters to represent the extent of hyperkeratosis. When skin became dry, rough and sometimes flakey in winter, the rates of amino acid conversion varied in the same patterns as seen in the experimentally induced hyperkeratosis. In addition to this, there were a number of nucleated cells in the stratum comeurn. These findings indicate that the lesion of rough skin in winter involves changes not only limited to the outermost cornified layer, but also in the viable epidermis." @default.
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• W2186534744 date "1984-01-01" @default.
• W2186534744 modified "2023-09-23" @default.
• W2186534744 title "Free amino acids of stratum corneum as a biochemical marker to evaluate dry skin" @default.
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